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KRTAP10-8 keratin associated protein 10-8 [ Homo sapiens (human) ]

Gene ID: 386681, updated on 10-Oct-2023

Summary

Official Symbol
KRTAP10-8provided by HGNC
Official Full Name
keratin associated protein 10-8provided by HGNC
Primary source
HGNC:HGNC:20525
See related
Ensembl:ENSG00000187766 AllianceGenome:HGNC:20525
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAP10.8; KRTAP18-8; KRTAP18.8
Summary
Enables identical protein binding activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See KRTAP10-8 in Genome Data Viewer
Location:
21q22.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (44612079..44612954)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (42972527..42973402)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (46031996..46032871)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene thrombospondin type laminin G domain and EAR repeats Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46011233-46011980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46011981-46012726 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46012727-46013473 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:46018864-46019624 Neighboring gene keratin associated protein 10-6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46020385-46021145 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46021146-46021905 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46022006-46022862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46022863-46023717 Neighboring gene keratin associated protein 10-7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46031985-46032634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46032635-46033283 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46036915-46037661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46045935-46046630 Neighboring gene keratin associated protein 10-9 Neighboring gene keratin associated protein 10-10

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin-associated protein 10-8
Names
high sulfur keratin-associated protein 10.8
keratin associated protein 18-8
keratin-associated protein 10.8
keratin-associated protein 18.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198695.2NP_941968.2  keratin-associated protein 10-8

    See identical proteins and their annotated locations for NP_941968.2

    Status: VALIDATED

    Source sequence(s)
    AB076355, AL773602
    Consensus CDS
    CCDS13713.1
    UniProtKB/Swiss-Prot
    A0JNW4, P60410
    Related
    ENSP00000335565.2, ENST00000334662.2
    Conserved Domains (2) summary
    pfam01500
    Location:58221
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam13885
    Location:98138
    Keratin_B2_2; Keratin, high sulfur B2 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    44612079..44612954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    42972527..42973402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)