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KRTAP10-8 keratin associated protein 10-8 [ Homo sapiens (human) ]

Gene ID: 386681, updated on 2-Nov-2024

Summary

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Official Symbol
KRTAP10-8provided by HGNC
Official Full Name
keratin associated protein 10-8provided by HGNC
Primary source
HGNC:HGNC:20525
See related
Ensembl:ENSG00000187766 AllianceGenome:HGNC:20525
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAP10.8; KRTAP18-8; KRTAP18.8
Summary
Enables identical protein binding activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See KRTAP10-8 in Genome Data Viewer
Location:
21q22.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (44612079..44612954)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (42972527..42973402)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (46031996..46032871)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene thrombospondin type laminin G domain and EAR repeats Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46011233-46011980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46011981-46012726 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46012727-46013473 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:46018864-46019624 Neighboring gene keratin associated protein 10-6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46020385-46021145 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46021146-46021905 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46022006-46022862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46022863-46023717 Neighboring gene keratin associated protein 10-7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46031985-46032634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46032635-46033283 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46036915-46037661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46045935-46046630 Neighboring gene keratin associated protein 10-9 Neighboring gene keratin associated protein 10-10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3. Shibuya K, et al. Genomics, 2004 Apr. PMID 15028290
  2. The DNA sequence of human chromosome 21. Hattori M, et al. Nature, 2000 May 18. PMID 10830953
  3. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. Chen S, et al. Nat Genet, 2018 Jul. PMID 29892012, Free PMC Article
  4. Widespread macromolecular interaction perturbations in human genetic disorders. Sahni N, et al. Cell, 2015 Apr 23. PMID 25910212, Free PMC Article
  5. Assessment of community efforts to advance network-based prediction of protein-protein interactions. Wang XW, et al. Nat Commun, 2023 Mar 22. PMID 36949045, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
keratin-associated protein 10-8
Names
high sulfur keratin-associated protein 10.8
keratin associated protein 18-8
keratin-associated protein 10.8
keratin-associated protein 18.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198695.2 → NP_941968.2  keratin-associated protein 10-8

    See identical proteins and their annotated locations for NP_941968.2

    Status: VALIDATED

    Source sequence(s)
    AB076355, AL773602
    Consensus CDS
    CCDS13713.1
    UniProtKB/Swiss-Prot
    A0JNW4, P60410
    Related
    ENSP00000335565.2, ENST00000334662.2
    Conserved Domains (2) summary
    pfam01500
    Location:58 → 221
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam13885
    Location:98 → 138
    Keratin_B2_2; Keratin, high sulfur B2 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    44612079..44612954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    42972527..42973402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60410.2 GenPept UniProtKB/Swiss-Prot:P60410

Gene LinkOut

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