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KRTAP10-4 keratin associated protein 10-4 [ Homo sapiens (human) ]

Gene ID: 386672, updated on 9-Sep-2022

Summary

Official Symbol
KRTAP10-4provided by HGNC
Official Full Name
keratin associated protein 10-4provided by HGNC
Primary source
HGNC:HGNC:20521
See related
Ensembl:ENSG00000215454 AllianceGenome:HGNC:20521
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAP10.4; KAP18-4; KRTAP10.4; KRTAP18-4; KRTAP18.4
Summary
This is an intronless gene located in a cluster of related genes on the q arm of chromosome 21. The proteins encoded by these genes form disulfide bonds with cysteine residues in hair keratins, thereby contributing to the structure and stability of hair fibers. [provided by RefSeq, Apr 2014]
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Genomic context

See KRTAP10-4 in Genome Data Viewer
Location:
21q22.3
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (44573729..44575371)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (42934129..42935771)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (45993606..45995248)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene thrombospondin type laminin G domain and EAR repeats Neighboring gene keratin associated protein 10-2 Neighboring gene keratin associated protein 10-3 Neighboring gene keratin associated protein 10-5 Neighboring gene keratin associated protein 10-6

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC149545, MGC149546

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin-associated protein 10-4
Names
high sulfur keratin-associated protein 10.4
keratin-associated protein 18.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198687.2NP_941960.2  keratin-associated protein 10-4

    See identical proteins and their annotated locations for NP_941960.2

    Status: REVIEWED

    Source sequence(s)
    AP001067
    Consensus CDS
    CCDS42957.1
    Related
    ENSP00000383225.3, ENST00000400374.4
    Conserved Domains (3) summary
    pfam01500
    Location:207387
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05287
    Location:52233
    PMG; PMG protein
    pfam13885
    Location:89130
    Keratin_B2_2; Keratin, high sulfur B2 protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    44573729..44575371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    42934129..42935771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)