Cdsn corneodesmosin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdsnprovided by MGI
Official Full Name: corneodesmosinprovided by MGI
Primary source: MGI:MGI:3505689
See related: Ensembl:ENSMUSG00000039518 AllianceGenome:MGI:3505689
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable protein homodimerization activity. Predicted to be involved in several processes, including amyloid fibril formation; corneocyte desquamation; and negative regulation of cornification. Predicted to be located in desmosome. Is expressed in skin. Human ortholog(s) of this gene implicated in alopecia; hypotrichosis 2; and peeling skin syndrome 1. Orthologous to human CDSN (corneodesmosin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in mammary gland adult (RPKM 28.2), stomach adult (RPKM 27.6) and 6 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 17 B1; 17 18.7 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (35854044..35867811)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (35543101..35557180)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results underscore the essential roles of CDSN in hair physiology and suggest functional relevance of CDSN gene polymorphisms to psoriasis susceptibility.
Title: Targeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

AI747712 (e-PCR)
- UniSTS:181012

Cdsn (e-PCR), detects polymorphism
- UniSTS:502652

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein homodimerization activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in corneocyte desquamation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cornification	ISO Inferred from Sequence Orthology more info
involved_in skin morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in skin morphogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in desmosome	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: corneodesmosin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.