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KIF25 kinesin family member 25 [ Homo sapiens (human) ]

Gene ID: 3834, updated on 11-Jun-2021

Summary

Official Symbol
KIF25provided by HGNC
Official Full Name
kinesin family member 25provided by HGNC
Primary source
HGNC:HGNC:6390
See related
Ensembl:ENSG00000125337 MIM:603815
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KNSL3
Summary
The protein encoded by this gene is a member of the kinesin-like protein family. Protein family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. However, the particular function of this gene product has not yet been determined. Two alternatively spliced transcript variants which encode products have been described. Other splice variants have been found that lack exon 2 and the initiation codon for translation. [provided by RefSeq, Jul 2008]
Expression
Biased expression in fat (RPKM 4.7) and placenta (RPKM 0.3) See more
Orthologs
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Genomic context

See KIF25 in Genome Data Viewer
Location:
6q27
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (167997671..168045106)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (168398351..168445771)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100128124 Neighboring gene KIF25 antisense RNA 1 Neighboring gene uncharacterized LOC105378135 Neighboring gene FERM domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
GeneReviews: Not available

General gene information

Markers

Homology

Clone Names

  • MGC163361

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent microtubule motor activity, minus-end-directed ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ATPase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
kinesin-like protein KIF25
Names
kinesin-like 3
kinesin-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005355.5NP_005346.3  kinesin-like protein KIF25 isoform 2

    See identical proteins and their annotated locations for NP_005346.3

    Status: REVIEWED

    Source sequence(s)
    AL589733
    Consensus CDS
    CCDS43530.1
    UniProtKB/Swiss-Prot
    Q9UIL4
    Conserved Domains (1) summary
    cl25583
    Location:31317
    Kinesin; Kinesin motor domain
  2. NM_030615.4NP_085118.2  kinesin-like protein KIF25 isoform 1

    See identical proteins and their annotated locations for NP_085118.2

    Status: REVIEWED

    Source sequence(s)
    AL589733
    Consensus CDS
    CCDS5305.1
    UniProtKB/Swiss-Prot
    Q9UIL4
    Related
    ENSP00000496229.1, ENST00000643607.3
    Conserved Domains (1) summary
    cl22853
    Location:31363
    Motor_domain; Myosin and Kinesin motor domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    167997671..168045106
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535803.3XP_011534105.1  kinesin-like protein KIF25 isoform X2

    See identical proteins and their annotated locations for XP_011534105.1

    UniProtKB/Swiss-Prot
    Q9UIL4
    Related
    ENSP00000252688.3, ENST00000351261.4
    Conserved Domains (1) summary
    cl25583
    Location:31317
    Kinesin; Kinesin motor domain
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