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Sbk3 SH3 domain binding kinase family, member 3 [ Mus musculus (house mouse) ]

Gene ID: 381835, updated on 2-Nov-2024

Summary

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Official Symbol
Sbk3provided by MGI
Official Full Name
SH3 domain binding kinase family, member 3provided by MGI
Primary source
MGI:MGI:2685924
See related
Ensembl:ENSMUSG00000085272 AllianceGenome:MGI:2685924
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1078; Sgk110
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in chromatin remodeling and protein phosphorylation. Orthologous to human SBK3 (SH3 domain binding kinase family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in heart adult (RPKM 17.5) and lung adult (RPKM 2.3) See more
Orthologs
human all
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Genomic context

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See Sbk3 in Genome Data Viewer
Location:
7 A1; 7 2.87 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4968246..4995756, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4965247..4981041, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene scavenger receptor cysteine rich family, 5 domains Neighboring gene STARR-positive B cell enhancer ABC_E6508 Neighboring gene SH3-binding domain kinase family, member 2 Neighboring gene zinc finger protein 579 Neighboring gene predicted gene, 53351

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The mouse kinome: discovery and comparative genomics of all mouse protein kinases. Caenepeel S, et al. Proc Natl Acad Sci U S A, 2004 Aug 10. PMID 15289607, Free PMC Article
  2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. First described as a protein kinase and named SgK110 (Sugen Kinase 110) after its human ortholog.
    Title: The mouse kinome: discovery and comparative genomics of all mouse protein kinases.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
uncharacterized serine/threonine-protein kinase SBK3
Names
SH3-binding domain kinase family member 3
sugen kinase 110
NP_001186970.1
XP_006540196.1
XP_006540198.1
XP_030098575.1
XP_036009088.1
XP_036009089.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001200041.1 → NP_001186970.1  uncharacterized serine/threonine-protein kinase SBK3

    See identical proteins and their annotated locations for NP_001186970.1

    Status: VALIDATED

    Source sequence(s)
    AC157563, AK138915
    Consensus CDS
    CCDS57475.1
    UniProtKB/Swiss-Prot
    P0C5K0
    Related
    ENSMUSP00000122507.2, ENSMUST00000144863.8
    Conserved Domains (1) summary
    cl21453
    Location:30 → 289
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    4968246..4995756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153196.1 → XP_036009089.1  uncharacterized serine/threonine-protein kinase SBK3 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:30 → 289
    PKc_like; Protein Kinases, catalytic domain

  2. XM_036153195.1 → XP_036009088.1  uncharacterized serine/threonine-protein kinase SBK3 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:30 → 289
    PKc_like; Protein Kinases, catalytic domain

  3. XM_030242715.1 → XP_030098575.1  uncharacterized serine/threonine-protein kinase SBK3 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:30 → 289
    PKc_like; Protein Kinases, catalytic domain

  4. XM_006540135.3 → XP_006540198.1  uncharacterized serine/threonine-protein kinase SBK3 isoform X2

    See identical proteins and their annotated locations for XP_006540198.1

    UniProtKB/Swiss-Prot
    P0C5K0
    Conserved Domains (1) summary
    cl21453
    Location:30 → 289
    PKc_like; Protein Kinases, catalytic domain

  5. XM_006540133.5 → XP_006540196.1  uncharacterized serine/threonine-protein kinase SBK3 isoform X1

    See identical proteins and their annotated locations for XP_006540196.1

    UniProtKB/Swiss-Prot
    D3Z5J0, E9QLM1, P0C5K0
    Related
    ENSMUSP00000120654.2, ENSMUST00000133272.2
    Conserved Domains (1) summary
    cl21453
    Location:49 → 308
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C5K0.2 GenPept UniProtKB/Swiss-Prot:P0C5K0

Gene LinkOut

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