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Lrrc43 leucine rich repeat containing 43 [ Mus musculus (house mouse) ]

Gene ID: 381741, updated on 5-Mar-2024

Summary

Official Symbol
Lrrc43provided by MGI
Official Full Name
leucine rich repeat containing 43provided by MGI
Primary source
MGI:MGI:2685907
See related
Ensembl:ENSMUSG00000063409 AllianceGenome:MGI:2685907
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1061
Summary
Orthologous to human LRRC43 (leucine rich repeat containing 43). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 53.6) See more
Orthologs
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Genomic context

See Lrrc43 in Genome Data Viewer
Location:
5 F; 5 63.01 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (123627349..123646268)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123489287..123508205)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31, pseudogene 6 Neighboring gene interleukin 31 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 Neighboring gene diablo, IAP-binding mitochondrial protein Neighboring gene microRNA 7647

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in axoneme assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
leucine-rich repeat-containing protein 43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033461.3NP_001028633.1  leucine-rich repeat-containing protein 43 isoform 1

    See identical proteins and their annotated locations for NP_001028633.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK133051, DV646947
    Consensus CDS
    CCDS19664.1
    UniProtKB/Swiss-Prot
    Q3TIS6, Q3TJS5, Q3V0L5
    UniProtKB/TrEMBL
    B9EKH4
    Related
    ENSMUSP00000091885.4, ENSMUST00000094327.10
    Conserved Domains (2) summary
    COG4886
    Location:154263
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:171194
    LRR_1; leucine-rich repeat [structural motif]
  2. NM_001289821.1NP_001276750.1  leucine-rich repeat-containing protein 43 isoform 2

    See identical proteins and their annotated locations for NP_001276750.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK133051, AK167729, DV646947
    Consensus CDS
    CCDS71662.1
    UniProtKB/TrEMBL
    B9EKH4
    Related
    ENSMUSP00000113933.2, ENSMUST00000121444.2
    Conserved Domains (2) summary
    COG4886
    Location:154263
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:171194
    LRR_1; leucine-rich repeat [structural motif]
  3. NM_001289822.1NP_001276751.1  leucine-rich repeat-containing protein 43 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK133051, AK167729, DV646947
    Consensus CDS
    CCDS80402.1
    UniProtKB/TrEMBL
    A0A0G2JGK7, B9EKH4
    Related
    ENSMUSP00000143602.2, ENSMUST00000196809.5
    Conserved Domains (2) summary
    COG4886
    Location:154263
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:171194
    LRR_1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    123627349..123646268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254637.2XP_030110497.1  leucine-rich repeat-containing protein 43 isoform X1

    Conserved Domains (2) summary
    COG4886
    Location:154263
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:171194
    LRR_1; leucine-rich repeat [structural motif]
  2. XM_006530400.5XP_006530463.1  leucine-rich repeat-containing protein 43 isoform X1

    Conserved Domains (2) summary
    COG4886
    Location:154263
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:171194
    LRR_1; leucine-rich repeat [structural motif]