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Fbrsl1 fibrosin-like 1 [ Mus musculus (house mouse) ]

Gene ID: 381668, updated on 5-Mar-2024

Summary

Official Symbol
Fbrsl1provided by MGI
Official Full Name
fibrosin-like 1provided by MGI
Primary source
MGI:MGI:1920907
See related
Ensembl:ENSMUSG00000043323 AllianceGenome:MGI:1920907
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1049; Gm29766; mKIAA1545; 2410025L10Rik
Summary
Is expressed in testis. Orthologous to human FBRSL1 (fibrosin like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 37.3), ovary adult (RPKM 25.5) and 27 other tissues See more
Orthologs
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Genomic context

Location:
5 F; 5 53.51 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110509617..110596369, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110361751..110448503, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 2 Neighboring gene leucine rich colipase-like 1 Neighboring gene STARR-seq mESC enhancer starr_13955 Neighboring gene STARR-positive B cell enhancer ABC_E3598 Neighboring gene STARR-seq mESC enhancer starr_13957 Neighboring gene predicted gene, 32996 Neighboring gene RIKEN cDNA A630023P12 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
fibrosin-1-like protein
Names
AUTS2-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142642.1NP_001136114.1  fibrosin-1-like protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AW492835, BC059932, BP764457, BU614458, BY733978, CA321720, CX204847
    Consensus CDS
    CCDS51609.1
    UniProtKB/TrEMBL
    A0A0G2JDI2, E9Q9T0
    Related
    ENSMUSP00000063879.6, ENSMUST00000069483.12
    Conserved Domains (1) summary
    pfam15336
    Location:564767
    Auts2; Autism susceptibility gene 2 protein
  2. NM_001317042.1NP_001303971.1  fibrosin-1-like protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC169384
    UniProtKB/TrEMBL
    A0A571BFB2
    Conserved Domains (1) summary
    PHA03247
    Location:395547
    PHA03247; large tegument protein UL36; Provisional
  3. NM_028596.2NP_082872.2  fibrosin-1-like protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate promoter and lacks an in-frame portion of the 5' coding region, compared to variant 1. It also lacks two alternate in-frame exons on the central coding region. The resulting isoform (2) has a shorter N-terminus and lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AK031967, AW492835, BC059932, BP764457, CA321720, CJ057461
    Consensus CDS
    CCDS39211.1
    UniProtKB/TrEMBL
    A0A0G2JFF2, E9PUB6
    Related
    ENSMUSP00000054613.7, ENSMUST00000056124.11
    Conserved Domains (1) summary
    pfam15336
    Location:150329
    Auts2; Autism susceptibility gene 2 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    110509617..110596369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_105032.1: Suppressed sequence

    Description
    NR_105032.1: This RefSeq was removed because the gene was discontinued.