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Fbrsl1 fibrosin-like 1 [ Mus musculus (house mouse) ]

Gene ID: 381668, updated on 2-Nov-2024

Summary

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Official Symbol
Fbrsl1provided by MGI
Official Full Name
fibrosin-like 1provided by MGI
Primary source
MGI:MGI:1920907
See related
Ensembl:ENSMUSG00000043323 AllianceGenome:MGI:1920907
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1049; Gm29766; mKIAA1545; 2410025L10Rik
Summary
Is expressed in cerebral cortex subventricular zone; cerebral cortex ventricular layer; and testis. Orthologous to human FBRSL1 (fibrosin like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 37.3), ovary adult (RPKM 25.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Fbrsl1 in Genome Data Viewer
Location:
5 F; 5 53.51 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110509617..110596369, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110361751..110448503, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 2 Neighboring gene leucine rich colipase-like 1 Neighboring gene STARR-seq mESC enhancer starr_13955 Neighboring gene STARR-positive B cell enhancer ABC_E3598 Neighboring gene STARR-seq mESC enhancer starr_13957 Neighboring gene predicted gene, 32996 Neighboring gene RIKEN cDNA A630023P12 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
fibrosin-1-like protein
Names
AUTS2-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142642.1 → NP_001136114.1  fibrosin-1-like protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AW492835, BC059932, BP764457, BU614458, BY733978, CA321720, CX204847
    Consensus CDS
    CCDS51609.1
    UniProtKB/TrEMBL
    A0A0G2JDI2, E9Q9T0
    Related
    ENSMUSP00000063879.6, ENSMUST00000069483.12
    Conserved Domains (1) summary
    pfam15336
    Location:564 → 767
    Auts2; Autism susceptibility gene 2 protein

  2. NM_001317042.1 → NP_001303971.1  fibrosin-1-like protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC169384
    UniProtKB/TrEMBL
    A0A571BFB2
    Conserved Domains (1) summary
    PHA03247
    Location:395 → 547
    PHA03247; large tegument protein UL36; Provisional

  3. NM_028596.2 → NP_082872.2  fibrosin-1-like protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate promoter and lacks an in-frame portion of the 5' coding region, compared to variant 1. It also lacks two alternate in-frame exons on the central coding region. The resulting isoform (2) has a shorter N-terminus and lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AK031967, AW492835, BC059932, BP764457, CA321720, CJ057461
    Consensus CDS
    CCDS39211.1
    UniProtKB/TrEMBL
    A0A0G2JFF2, E9PUB6
    Related
    ENSMUSP00000054613.7, ENSMUST00000056124.11
    Conserved Domains (1) summary
    pfam15336
    Location:150 → 329
    Auts2; Autism susceptibility gene 2 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    110509617..110596369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_105032.1: Suppressed sequence

    Description
    NR_105032.1: This RefSeq was removed because the gene was discontinued.
Nucleotide Protein Strain
Heading Accession and Version

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