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Trp53rka transformation related protein 53 regulating kinase A [ Mus musculus (house mouse) ]

Gene ID: 381406, updated on 5-Mar-2024

Summary

Official Symbol
Trp53rkaprovided by MGI
Official Full Name
transformation related protein 53 regulating kinase Aprovided by MGI
Primary source
MGI:MGI:1918294
See related
Ensembl:ENSMUSG00000039725 AllianceGenome:MGI:1918294
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810408M09Rik
Summary
Predicted to enable p53 binding activity and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and tRNA threonylcarbamoyladenosine metabolic process. Predicted to be located in cytoplasm. Predicted to be part of EKC/KEOPS complex. Predicted to be active in nucleus. Is expressed in embryo. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 4. Orthologous to human TP53RK (TP53 regulating kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 16.1), CNS E11.5 (RPKM 14.2) and 28 other tissues See more
Orthologs
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Genomic context

See Trp53rka in Genome Data Viewer
Location:
2 H3; 2 85.64 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (165332032..165335244, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (165490112..165493314, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene osteoclast stimulatory transmembrane protein Neighboring gene solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 Neighboring gene origin of replication near adenosine deaminase Neighboring gene predicted gene 14437 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 10 Neighboring gene EYA transcriptional coactivator and phosphatase 2 Neighboring gene predicted gene, 29993

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Clone Names

  • MGC102419

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in tRNA threonylcarbamoyladenosine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of EKC/KEOPS complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of EKC/KEOPS complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
TP53-regulating kinase
NP_001007582.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007581.2NP_001007582.1  TP53-regulating kinase

    See identical proteins and their annotated locations for NP_001007582.1

    Status: VALIDATED

    Source sequence(s)
    AL591064
    Consensus CDS
    CCDS17082.1
    UniProtKB/Swiss-Prot
    Q91W37, Q99PW4, Q9CZ32
    UniProtKB/TrEMBL
    Q5U452
    Related
    ENSMUSP00000045141.6, ENSMUST00000039007.7
    Conserved Domains (1) summary
    COG3642
    Location:27244
    Bud32; tRNA A-37 threonylcarbamoyl transferase component Bud32 [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    165332032..165335244 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)