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Nsl1 NSL1, MIS12 kinetochore complex component [ Mus musculus (house mouse) ]

Gene ID: 381318, updated on 2-Nov-2024

Summary

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Official Symbol
Nsl1provided by MGI
Official Full Name
NSL1, MIS12 kinetochore complex componentprovided by MGI
Primary source
MGI:MGI:2685830
See related
Ensembl:ENSMUSG00000062510 AllianceGenome:MGI:2685830
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm105; Gm984; 4833432M17Rik
Summary
Predicted to be involved in cell division and mitotic sister chromatid segregation. Predicted to be located in kinetochore and nuclear speck. Predicted to be part of MIS12/MIND type complex. Orthologous to human NSL1 (NSL1 component of MIS12 kinetochore complex). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E11.5 (RPKM 6.8), liver E14 (RPKM 5.6) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Nsl1 in Genome Data Viewer
Location:
1 H6; 1 96.28 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (190794710..190816755)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (191062996..191084558)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene feline leukemia virus subgroup C cellular receptor 1 Neighboring gene RIKEN cDNA A230020J21 gene Neighboring gene STARR-positive B cell enhancer ABC_E223 Neighboring gene spermatogenesis associated 45 Neighboring gene TatD DNase domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E4404 Neighboring gene basic leucine zipper transcription factor, ATF-like 3 Neighboring gene predicted gene, 46178

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A blueprint for kinetochores - new insights into the molecular mechanics of cell division. Lampert F, et al. Nat Rev Mol Cell Biol, 2011 Jun 2. PMID 21633384
  2. The KMN protein network--chief conductors of the kinetochore orchestra. Varma D, et al. J Cell Sci, 2012 Dec 15. PMID 23418356, Free PMC Article
  3. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in attachment of spindle microtubules to kinetochore NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid segregation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of MIS12/MIND type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MIS12/MIND type complex ISO
Inferred from Sequence Orthology
more info
  
part_of MIS12/MIND type complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of MIS12/MIND type complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
located_in spindle pole NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
kinetochore-associated protein NSL1 homolog
Names
NSL1, MIND kinetochore complex component, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198654.3 → NP_941056.3  kinetochore-associated protein NSL1 homolog

    Status: VALIDATED

    Source sequence(s)
    AC138229
    Consensus CDS
    CCDS15614.1
    UniProtKB/Swiss-Prot
    Q8K305
    UniProtKB/TrEMBL
    E9QME3
    Related
    ENSMUSP00000077380.7, ENSMUST00000078259.8
    Conserved Domains (1) summary
    pfam08641
    Location:82 → 196
    Mis14; Kinetochore protein Mis14 like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    190794710..190816755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321425.2 → XP_017176914.1  kinetochore-associated protein NSL1 homolog isoform X1

    Conserved Domains (1) summary
    pfam08641
    Location:44 → 158
    Mis14; Kinetochore protein Mis14 like

  2. XM_011238922.4 → XP_011237224.1  kinetochore-associated protein NSL1 homolog isoform X3

    UniProtKB/TrEMBL
    E9Q3W6, Q8CDX2
    Related
    ENSMUSP00000115289.2, ENSMUST00000139340.8
    Conserved Domains (1) summary
    pfam08641
    Location:82 → 169
    Mis14; Kinetochore protein Mis14 like

  3. XM_006497181.5 → XP_006497244.1  kinetochore-associated protein NSL1 homolog isoform X2

    See identical proteins and their annotated locations for XP_006497244.1

    UniProtKB/TrEMBL
    D3Z4S2
    Related
    ENSMUSP00000076220.6, ENSMUST00000076952.12
    Conserved Domains (1) summary
    pfam08641
    Location:82 → 167
    Mis14; Kinetochore protein Mis14 like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K305.1 GenPept UniProtKB/Swiss-Prot:Q8K305

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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