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Nsl1 NSL1, MIS12 kinetochore complex component [ Mus musculus (house mouse) ]

Gene ID: 381318, updated on 8-Dec-2022

Summary

Official Symbol
Nsl1provided by MGI
Official Full Name
NSL1, MIS12 kinetochore complex componentprovided by MGI
Primary source
MGI:MGI:2685830
See related
Ensembl:ENSMUSG00000062510 AllianceGenome:MGI:2685830
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm105; Gm984; 4833432M17Rik
Summary
Predicted to be involved in mitotic sister chromatid segregation. Predicted to act upstream of or within cell division and chromosome segregation. Predicted to be located in kinetochore and nuclear speck. Predicted to be part of MIS12/MIND type complex. Orthologous to human NSL1 (NSL1 component of MIS12 kinetochore complex). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 6.8), liver E14 (RPKM 5.6) and 13 other tissues See more
Orthologs
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Genomic context

See Nsl1 in Genome Data Viewer
Location:
1; 1 H6
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (190794710..190816755)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (191062996..191084558)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene feline leukemia virus subgroup C cellular receptor 1 Neighboring gene RIKEN cDNA A230020J21 gene Neighboring gene spermatogenesis associated 45 Neighboring gene TatD DNase domain containing 3 Neighboring gene basic leucine zipper transcription factor, ATF-like 3 Neighboring gene predicted gene, 46178

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of MIS12/MIND type complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of MIS12/MIND type complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore NAS
Non-traceable Author Statement
more info
PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kinetochore-associated protein NSL1 homolog
Names
NSL1, MIND kinetochore complex component, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198654.3NP_941056.3  kinetochore-associated protein NSL1 homolog

    Status: VALIDATED

    Source sequence(s)
    AC138229
    Consensus CDS
    CCDS15614.1
    UniProtKB/TrEMBL
    E9QME3
    Related
    ENSMUSP00000077380.7, ENSMUST00000078259.8
    Conserved Domains (1) summary
    pfam08641
    Location:82196
    Mis14; Kinetochore protein Mis14 like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    190794710..190816755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321425.2XP_017176914.1  kinetochore-associated protein NSL1 homolog isoform X1

    Conserved Domains (1) summary
    pfam08641
    Location:44158
    Mis14; Kinetochore protein Mis14 like
  2. XM_011238922.4XP_011237224.1  kinetochore-associated protein NSL1 homolog isoform X3

    UniProtKB/TrEMBL
    A0A8C6ICP1, E9Q3W6
    Related
    ENSMUSP00000115289.2, ENSMUST00000139340.8
    Conserved Domains (1) summary
    pfam08641
    Location:82169
    Mis14; Kinetochore protein Mis14 like
  3. XM_006497181.5XP_006497244.1  kinetochore-associated protein NSL1 homolog isoform X2

    See identical proteins and their annotated locations for XP_006497244.1

    Related
    ENSMUSP00000076220.6, ENSMUST00000076952.12
    Conserved Domains (1) summary
    pfam08641
    Location:82167
    Mis14; Kinetochore protein Mis14 like