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Lyrm4 LYR motif containing 4 [ Mus musculus (house mouse) ]

Gene ID: 380840, updated on 5-Mar-2024

Summary

Official Symbol
Lyrm4provided by MGI
Official Full Name
LYR motif containing 4provided by MGI
Primary source
MGI:MGI:2683538
See related
Ensembl:ENSMUSG00000046573 AllianceGenome:MGI:2683538
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm903
Summary
Predicted to be involved in iron-sulfur cluster assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 19. Orthologous to human LYRM4 (LYR motif containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 6.6), cortex adult (RPKM 6.3) and 28 other tissues See more
Orthologs
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Genomic context

See Lyrm4 in Genome Data Viewer
Location:
13 A3.3; 13 14.44 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (36162778..36301543, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (35978797..36117357, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34183 Neighboring gene ribonuclease P 40 subunit Neighboring gene STARR-seq mESC enhancer starr_34184 Neighboring gene protein phosphatase 1, regulatory subunit 3G Neighboring gene predicted gene, 30127 Neighboring gene transmembrane p24 trafficking protein 10, pseudogene Neighboring gene predicted gene, 18132 Neighboring gene STARR-positive B cell enhancer ABC_E7224 Neighboring gene STARR-seq mESC enhancer starr_34186 Neighboring gene phenylalanine-tRNA synthetase 2, mitochondrial Neighboring gene STARR-seq mESC enhancer starr_34187 Neighboring gene STARR-seq mESC enhancer starr_34188 Neighboring gene predicted gene, 40912 Neighboring gene STARR-seq mESC enhancer starr_34189 Neighboring gene STARR-seq mESC enhancer starr_34190 Neighboring gene STARR-seq mESC enhancer starr_34191 Neighboring gene STARR-seq mESC enhancer starr_34192 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:36458293-36458547 Neighboring gene STARR-seq mESC enhancer starr_34193 Neighboring gene high mobility group box 1-like pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC38622

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in [2Fe-2S] cluster assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of [4Fe-4S] cluster assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in iron-sulfur cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in iron-sulfur cluster assembly NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of L-cysteine desulfurase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of iron-sulfur cluster assembly complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of mitochondrial iron-sulfur cluster assembly complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of mitochondrial iron-sulfur cluster assembly complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
LYR motif-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201358.3NP_958746.1  LYR motif-containing protein 4

    See identical proteins and their annotated locations for NP_958746.1

    Status: VALIDATED

    Source sequence(s)
    AC124562, AC134860
    Consensus CDS
    CCDS36633.1
    UniProtKB/Swiss-Prot
    Q8K215
    Related
    ENSMUSP00000060779.7, ENSMUST00000053265.8
    Conserved Domains (1) summary
    cd20264
    Location:876
    Complex1_LYR_LYRM4; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    36162778..36301543 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)