Ighg2a immunoglobulin heavy constant gamma 2A [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Ighg2aprovided by MGI
Official Full Name: immunoglobulin heavy constant gamma 2Aprovided by MGI
Primary source: MGI:MGI:96443
See related: IMGT/GENE-DB:IGHG2A; AllianceGenome:MGI:96443
Gene type: other
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Igh-1; Igh-1a; 1810060O09Rik
Summary: Enables antigen binding activity. Acts upstream of or within several processes, including phagocytosis; positive regulation of immune response; and regulation of vesicle-mediated transport. Located in multivesicular body. Part of immunoglobulin complex, circulating. Orthologous to several human genes including IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker)); IGHG2 (immunoglobulin heavy constant gamma 2 (G2m marker)); and IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker)). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: not in current annotation release
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Genomic context

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Location:: 12 F2; 12

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The two investigated Fc mutations in the mouse IgG backbone lead to similar "silencing" properties.
Title: Highly reduced binding to high and low affinity mouse Fc gamma receptors by L234A/L235A and N297A Fc mutations engineered into mouse IgG2a.
On the one hand, IgG2a enhances antibody responses via activating Fc gamma receptors, and on the other hand, IgG2a sets an upper limit for the same antibody response via the Fc gamma IIB receptor.
Title: IgG2a-mediated enhancement of antibody and T cell responses and its relation to inhibitory and activating Fc gamma receptors.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Igh-1 (e-PCR), detects polymorphism
- UniSTS:226082

Igh-1 (e-PCR), detects polymorphism
- UniSTS:226136

Other Names

Ig heavy chain Mem5
MLT2-23 heavy chain
immunoglobulin gamma-2a heavy chain
immunoglobulin heavy chain 1 (serum IgG2a)
immunoglobulin heavy chain 1a (serum IgG2a)

Clone Names

MGC18977, MGC102662, MGC118125

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Fc-gamma receptor I complex binding	ISO Inferred from Sequence Orthology more info
enables antigen binding	IBA Inferred from Biological aspect of Ancestor more info
enables antigen binding	IDA Inferred from Direct Assay more info	PubMed
enables immunoglobulin receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within antibody-dependent cellular cytotoxicity	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within antigen processing and presentation	IDA Inferred from Direct Assay more info
involved_in complement activation, classical pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within complement activation, classical pathway	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within early endosome to late endosome transport	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within endosome to lysosome transport	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within humoral immune response mediated by circulating immunoglobulin	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within immunoglobulin mediated immune response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phagocytosis, engulfment	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phagocytosis, recognition	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of B cell activation	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within positive regulation of endocytosis	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within positive regulation of immune response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of phagocytosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of type I hypersensitivity	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within positive regulation of type IIa hypersensitivity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of proteolysis	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of IgG immunoglobulin complex	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of immunoglobulin complex, circulating	IBA Inferred from Biological aspect of Ancestor more info
part_of immunoglobulin complex, circulating	IDA Inferred from Direct Assay more info	PubMed
located_in multivesicular body	IDA Inferred from Direct Assay more info