Format

Send to:

Choose Destination

KIFC3 kinesin family member C3 [ Homo sapiens (human) ]

Gene ID: 3801, updated on 6-Jan-2019

Summary

Official Symbol
KIFC3provided by HGNC
Official Full Name
kinesin family member C3provided by HGNC
Primary source
HGNC:HGNC:6326
See related
Ensembl:ENSG00000140859 MIM:604535
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the kinesin-14 family of microtubule motors. Members of this family play a role in the formation, maintenance and remodeling of the bipolar mitotic spindle. The protein encoded by this gene has cytoplasmic functions in the interphase cells. It may also be involved in the final stages of cytokinesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Expression
Broad expression in kidney (RPKM 11.2), testis (RPKM 9.9) and 24 other tissues See more
Orthologs

Genomic context

See KIFC3 in Genome Data Viewer
Location:
16q21
Exon count:
34
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (57758217..57863053, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57792129..57896957, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene mitochondrial carrier 2 pseudogene Neighboring gene dynein regulatory complex subunit 7 Neighboring gene uncharacterized LOC107984852 Neighboring gene katanin regulatory subunit B1 Neighboring gene microRNA 6772 Neighboring gene uncharacterized LOC388282 Neighboring gene RNA, U6 small nuclear 20, pseudogene Neighboring gene cyclic nucleotide gated channel beta 1 Neighboring gene testis, prostate and placenta expressed

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34694, DKFZp686D23201

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent microtubule motor activity, minus-end-directed IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi organization IEA
Inferred from Electronic Annotation
more info
 
epithelial cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
visual perception TAS
Traceable Author Statement
more info
PubMed 
zonula adherens maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zonula adherens IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130099.1NP_001123571.1  kinesin-like protein KIFC3 isoform 3

    See identical proteins and their annotated locations for NP_001123571.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream start codon, compared to variant 4. It encodes isoform 3, which is shorter than isoform 4. Variants 3, 8 and 9 encode the same isoform (3).
    Source sequence(s)
    AK291737, BC008014, DC381406
    Consensus CDS
    CCDS45494.1
    UniProtKB/Swiss-Prot
    Q9BVG8
    Related
    ENSP00000396399.2, ENST00000421376.6
    Conserved Domains (2) summary
    cd01366
    Location:304631
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    cl25732
    Location:3301
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_001130100.2NP_001123572.1  kinesin-like protein KIFC3 isoform 2

    See identical proteins and their annotated locations for NP_001123572.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream start codon, compared to variant 4. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 4.
    Source sequence(s)
    AB209290, AK291737, BC008014, DA989120
    Consensus CDS
    CCDS45493.1
    UniProtKB/Swiss-Prot
    Q9BVG8
    Related
    ENSP00000401696.2, ENST00000445690.6
    Conserved Domains (2) summary
    cd01366
    Location:443770
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    cl25732
    Location:102440
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_001318710.1NP_001305639.1  kinesin-like protein KIFC3 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AK296995, BC041132, BE384068
    Consensus CDS
    CCDS81989.1
    UniProtKB/Swiss-Prot
    Q9BVG8
    Related
    ENSP00000442008.1, ENST00000541240.5
    Conserved Domains (2) summary
    cd01366
    Location:465792
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    cl25732
    Location:124462
    SMC_N; RecF/RecN/SMC N terminal domain
  4. NM_001318711.1NP_001305640.1  kinesin-like protein KIFC3 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the coding region and uses an alternate start codon, compared to variant 4. It encodes isoform 5, which has a shorter and distinct N-terminus, compared to isoform 4.
    Source sequence(s)
    AK291737, AK299431, BC041132
    UniProtKB/Swiss-Prot
    Q9BVG8
    UniProtKB/TrEMBL
    B7Z5U4
    Conserved Domains (3) summary
    cd01366
    Location:385712
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam00225
    Location:393710
    Kinesin; Kinesin motor domain
    cl12013
    Location:119306
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  5. NM_001318712.1NP_001305641.1  kinesin-like protein KIFC3 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the coding region and uses an alternate start codon, compared to variant 4. It encodes isoform 6, which has a shorter and distinct N-terminus, compared to isoform 4.
    Source sequence(s)
    AK296995, AK302743, BC041132, BC047051
    Consensus CDS
    CCDS81988.1
    UniProtKB/Swiss-Prot
    Q9BVG8
    UniProtKB/TrEMBL
    B7Z808, F5H3M2
    Related
    ENSP00000438805.2, ENST00000540079.6
    Conserved Domains (2) summary
    cd01366
    Location:341668
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    cl25732
    Location:40338
    SMC_N; RecF/RecN/SMC N terminal domain
  6. NM_001318713.1NP_001305642.1  kinesin-like protein KIFC3 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon and uses an alternate splice site in the coding region, compared to variant 4. It encodes isoform 7, which is shorter than isoform 4.
    Source sequence(s)
    AK296995, AK303021, BC041132, BC047051, DC402000
    Consensus CDS
    CCDS81987.1
    UniProtKB/Swiss-Prot
    Q9BVG8
    UniProtKB/TrEMBL
    B7Z896
    Related
    ENSP00000444012.1, ENST00000543930.5
    Conserved Domains (2) summary
    cd01366
    Location:304628
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    cl25732
    Location:3301
    SMC_N; RecF/RecN/SMC N terminal domain
  7. NM_001318714.1NP_001305643.1  kinesin-like protein KIFC3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream start codon, compared to variant 4. It encodes isoform 3, which is shorter than isoform 4. Variants 3, 8 and 9 encode the same isoform (3).
    Source sequence(s)
    AK296995, BC034234, BC041132, BC047051, DC402000
    Consensus CDS
    CCDS45494.1
    UniProtKB/Swiss-Prot
    Q9BVG8
    Related
    ENSP00000456239.1, ENST00000562903.5
    Conserved Domains (2) summary
    cd01366
    Location:304631
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    cl25732
    Location:3301
    SMC_N; RecF/RecN/SMC N terminal domain
  8. NM_001318715.1NP_001305644.1  kinesin-like protein KIFC3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream start codon, compared to variant 4. It encodes isoform 3, which is shorter than isoform 4. Variants 3, 8 and 9 encode the same isoform (3).
    Source sequence(s)
    AK291737, BC041132, BC047051
    Consensus CDS
    CCDS45494.1
    UniProtKB/Swiss-Prot
    Q9BVG8
    Related
    ENSP00000454659.1, ENST00000465878.6
    Conserved Domains (2) summary
    cd01366
    Location:304631
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    cl25732
    Location:3301
    SMC_N; RecF/RecN/SMC N terminal domain
  9. NM_005550.3NP_005541.3  kinesin-like protein KIFC3 isoform 1

    See identical proteins and their annotated locations for NP_005541.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and 5' coding region, uses a downstream start codon and lacks an exon in the 3' coding region, compared to variant 4. It encodes isoform 1, which is shorter and has distinct N- and C-termini, compared to isoform 4.
    Source sequence(s)
    AC092118, BC001211
    Consensus CDS
    CCDS10789.2
    UniProtKB/Swiss-Prot
    Q9BVG8
    Related
    ENSP00000368976.4, ENST00000379655.8
    Conserved Domains (2) summary
    cd01366
    Location:443770
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    cl25732
    Location:102440
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. NR_134678.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) contains multiple differences, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK295926, AK296995, BC041132, BC047051, DC402000
    Related
    ENST00000564136.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    57758217..57863053 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523075.1XP_011521377.1  kinesin-like protein KIFC3 isoform X7

    Conserved Domains (3) summary
    cd01366
    Location:492819
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam00225
    Location:500817
    Kinesin; Kinesin motor domain
    cl12013
    Location:226413
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. XM_011523076.1XP_011521378.1  kinesin-like protein KIFC3 isoform X8

    Conserved Domains (3) summary
    cd01366
    Location:492819
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam00225
    Location:500817
    Kinesin; Kinesin motor domain
    cl12013
    Location:226413
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  3. XM_005255937.1XP_005255994.1  kinesin-like protein KIFC3 isoform X4

    Conserved Domains (3) summary
    cd01366
    Location:606933
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam00225
    Location:614931
    Kinesin; Kinesin motor domain
    cl12013
    Location:340527
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  4. XM_017023221.1XP_016878710.1  kinesin-like protein KIFC3 isoform X5

  5. XM_006721188.1XP_006721251.1  kinesin-like protein KIFC3 isoform X3

    Conserved Domains (3) summary
    cd01366
    Location:632959
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam00225
    Location:640957
    Kinesin; Kinesin motor domain
    cl12013
    Location:366553
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  6. XM_011523077.1XP_011521379.1  kinesin-like protein KIFC3 isoform X9

    See identical proteins and their annotated locations for XP_011521379.1

    Conserved Domains (3) summary
    cd01366
    Location:471798
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam00225
    Location:479796
    Kinesin; Kinesin motor domain
    cl12013
    Location:205392
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  7. XM_017023223.1XP_016878712.1  kinesin-like protein KIFC3 isoform X10

  8. XM_017023219.1XP_016878708.1  kinesin-like protein KIFC3 isoform X1

  9. XM_017023220.1XP_016878709.1  kinesin-like protein KIFC3 isoform X2

  10. XM_017023226.1XP_016878715.1  kinesin-like protein KIFC3 isoform X12

    Conserved Domains (3) summary
    cd01366
    Location:385712
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam00225
    Location:393710
    Kinesin; Kinesin motor domain
    cl12013
    Location:119306
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  11. XM_017023227.1XP_016878716.1  kinesin-like protein KIFC3 isoform X13

    Conserved Domains (3) summary
    cd01366
    Location:385712
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam00225
    Location:393710
    Kinesin; Kinesin motor domain
    cl12013
    Location:119306
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  12. XM_024450269.1XP_024306037.1  kinesin-like protein KIFC3 isoform X15

    Conserved Domains (2) summary
    cd01366
    Location:304631
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    cl25732
    Location:3301
    SMC_N; RecF/RecN/SMC N terminal domain
  13. XM_017023222.1XP_016878711.1  kinesin-like protein KIFC3 isoform X6

  14. XM_024450265.1XP_024306033.1  kinesin-like protein KIFC3 isoform X14

    Conserved Domains (2) summary
    cd01366
    Location:304631
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    cl25732
    Location:3301
    SMC_N; RecF/RecN/SMC N terminal domain
  15. XM_011523078.1XP_011521380.1  kinesin-like protein KIFC3 isoform X14

    See identical proteins and their annotated locations for XP_011521380.1

    Conserved Domains (2) summary
    cd01366
    Location:304631
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    cl25732
    Location:3301
    SMC_N; RecF/RecN/SMC N terminal domain
  16. XM_005255944.1XP_005256001.1  kinesin-like protein KIFC3 isoform X12

    Conserved Domains (3) summary
    cd01366
    Location:385712
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam00225
    Location:393710
    Kinesin; Kinesin motor domain
    cl12013
    Location:119306
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  17. XM_017023224.1XP_016878713.1  kinesin-like protein KIFC3 isoform X6

  18. XM_024450267.1XP_024306035.1  kinesin-like protein KIFC3 isoform X14

    Conserved Domains (2) summary
    cd01366
    Location:304631
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    cl25732
    Location:3301
    SMC_N; RecF/RecN/SMC N terminal domain
  19. XM_024450266.1XP_024306034.1  kinesin-like protein KIFC3 isoform X14

    Conserved Domains (2) summary
    cd01366
    Location:304631
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    cl25732
    Location:3301
    SMC_N; RecF/RecN/SMC N terminal domain
  20. XM_011523079.1XP_011521381.1  kinesin-like protein KIFC3 isoform X14

    See identical proteins and their annotated locations for XP_011521381.1

    Conserved Domains (2) summary
    cd01366
    Location:304631
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    cl25732
    Location:3301
    SMC_N; RecF/RecN/SMC N terminal domain
  21. XM_024450268.1XP_024306036.1  kinesin-like protein KIFC3 isoform X14

    Conserved Domains (2) summary
    cd01366
    Location:304631
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    cl25732
    Location:3301
    SMC_N; RecF/RecN/SMC N terminal domain
  22. XM_017023225.1XP_016878714.1  kinesin-like protein KIFC3 isoform X11

Support Center