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KCNS3 potassium voltage-gated channel modifier subfamily S member 3 [ Homo sapiens (human) ]

Gene ID: 3790, updated on 13-Mar-2020

Summary

Official Symbol
KCNS3provided by HGNC
Official Full Name
potassium voltage-gated channel modifier subfamily S member 3provided by HGNC
Primary source
HGNC:HGNC:6302
See related
Ensembl:ENSG00000170745 MIM:603888
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KV9.3
Summary
Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
Expression
Broad expression in lung (RPKM 12.4), placenta (RPKM 5.3) and 18 other tissues See more
Orthologs

Genomic context

See KCNS3 in Genome Data Viewer
Location:
2p24.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (17877847..17932961)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (18059105..18114225)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112267888 Neighboring gene mesogenin 1 Neighboring gene zona pellucida glycoprotein AX, pseudogene Neighboring gene uncharacterized LOC105373451 Neighboring gene uncharacterized LOC105373454

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9481

Gene Ontology Provided by GOA

Function Evidence Code Pubs
delayed rectifier potassium channel activity TAS
Traceable Author Statement
more info
PubMed 
potassium channel regulator activity TAS
Traceable Author Statement
more info
PubMed 
voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion transport TAS
Traceable Author Statement
more info
PubMed 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
regulation of insulin secretion TAS
Traceable Author Statement
more info
 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
potassium voltage-gated channel subfamily S member 3
Names
Shab-related delayed-rectifier K+ channel alpha subunit 3
delayed-rectifier K(+) channel alpha subunit 3
potassium voltage-gated channel delayed-rectifier protein S3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
voltage-gated potassium channel protein Kv9.3
voltage-gated potassium channel subunit Kv9.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012873.1 RefSeqGene

    Range
    4980..59281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001282428.1NP_001269357.1  potassium voltage-gated channel subfamily S member 3

    See identical proteins and their annotated locations for NP_001269357.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' terminal exon, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK314451, BC015947, DA921825
    Consensus CDS
    CCDS1692.1
    UniProtKB/Swiss-Prot
    Q9BQ31
    Related
    ENSP00000385968.1, ENST00000403915.5
    Conserved Domains (4) summary
    smart00225
    Location:44122
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:219417
    Ion_trans; Ion transport protein
    pfam02214
    Location:17116
    BTB_2; BTB/POZ domain
    pfam07885
    Location:329411
    Ion_trans_2; Ion channel
  2. NM_002252.5NP_002243.3  potassium voltage-gated channel subfamily S member 3

    See identical proteins and their annotated locations for NP_002243.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    AC093731
    Consensus CDS
    CCDS1692.1
    UniProtKB/Swiss-Prot
    Q9BQ31
    Related
    ENSP00000305824.4, ENST00000304101.9
    Conserved Domains (4) summary
    smart00225
    Location:44122
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:219417
    Ion_trans; Ion transport protein
    pfam02214
    Location:17116
    BTB_2; BTB/POZ domain
    pfam07885
    Location:329411
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    17877847..17932961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532825.1XP_011531127.1  potassium voltage-gated channel subfamily S member 3 isoform X1

    See identical proteins and their annotated locations for XP_011531127.1

    UniProtKB/Swiss-Prot
    Q9BQ31
    Conserved Domains (4) summary
    smart00225
    Location:44122
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:219417
    Ion_trans; Ion transport protein
    pfam02214
    Location:17116
    BTB_2; BTB/POZ domain
    pfam07885
    Location:329411
    Ion_trans_2; Ion channel
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