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ARL4D ADP ribosylation factor like GTPase 4D [ Homo sapiens (human) ]

Gene ID: 379, updated on 17-Jun-2019

Summary

Official Symbol
ARL4Dprovided by HGNC
Official Full Name
ADP ribosylation factor like GTPase 4Dprovided by HGNC
Primary source
HGNC:HGNC:656
See related
Ensembl:ENSG00000175906 MIM:600732
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARL6; ARF4L
Summary
ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. Mutations in this gene have been associated with Bardet-Biedl syndrome (BBS). [provided by RefSeq, Jul 2008]
Expression
Broad expression in thyroid (RPKM 16.5), esophagus (RPKM 15.6) and 20 other tissues See more
Orthologs

Genomic context

See ARL4D in Genome Data Viewer
Location:
17q21.31
Exon count:
3
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (43398993..43401137)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41476353..41478504)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 910 Neighboring gene RNA, U2 small nuclear 4, pseudogene Neighboring gene RNA, U6 small nuclear 1137, pseudogene Neighboring gene RNA, U6 small nuclear 470, pseudogene Neighboring gene MIR2117 host gene Neighboring gene microRNA 2117

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein secretion TAS
Traceable Author Statement
more info
PubMed 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ADP-ribosylation factor-like protein 4D
Names
ADP-ribosylation factor-like 4D
ADP-ribosylation factor-like 6
ADP-ribosylation factor-like protein 4L

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001661.4NP_001652.2  ADP-ribosylation factor-like protein 4D

    See identical proteins and their annotated locations for NP_001652.2

    Status: REVIEWED

    Source sequence(s)
    AC087650, BC000043, BI547763, BM682844
    Consensus CDS
    CCDS11463.1
    UniProtKB/Swiss-Prot
    P49703
    Related
    ENSP00000322628.2, ENST00000320033.5
    Conserved Domains (1) summary
    cl21455
    Location:19201
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    43398993..43401137
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524782.2XP_011523084.1  ADP-ribosylation factor-like protein 4D isoform X1

    See identical proteins and their annotated locations for XP_011523084.1

    UniProtKB/Swiss-Prot
    P49703
    Conserved Domains (1) summary
    cl21455
    Location:19201
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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