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Terc telomerase RNA component [ Rattus norvegicus (Norway rat) ]

Gene ID: 378461, updated on 11-Apr-2024

Summary

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Official Symbol
Tercprovided by RGD
Official Full Name
telomerase RNA componentprovided by RGD
Primary source
RGD:727802
See related
AllianceGenome:RGD:727802
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tr
Summary
Predicted to enable template for synthesis of G-rich strand of telomere DNA activity. Involved in negative regulation of cell differentiation. Predicted to be part of telomerase holoenzyme complex. Human ortholog(s) of this gene implicated in autosomal dominant dyskeratosis congenita 1; cervix uteri carcinoma in situ; and prostate cancer. Orthologous to human TERC (telomerase RNA component). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
2q24
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (114744148..114744535)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (112815654..112816041)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (116432723..116433110)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene myoneurin Neighboring gene transfer RNA valine (anticodon AAC) 1 Neighboring gene actin-related protein T3 Neighboring gene serine/arginine-rich splicing factor 7 pseudogene Neighboring gene uncharacterized LOC120100572

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genomic integration of oncogenic HPV and gain of the human telomerase gene TERC at 3q26 are strongly associated events in the progression of uterine cervical dysplasia to invasive cancer. Hopman AH, et al. J Pathol, 2006 Dec. PMID 17054308
  2. Dyskerin expression influences the level of ribosomal RNA pseudo-uridylation and telomerase RNA component in human breast cancer. Montanaro L, et al. J Pathol, 2006 Sep. PMID 16841302
  3. Detection of human telomerase RNA in the tumour-surrounding mucosa of bladder carcinomas as a marker for premalignant transformation. Leuenroth S, et al. BJU Int, 2005 Sep. PMID 16104909
  4. Gene amplifications associated with the development of hormone-resistant prostate cancer. Edwards J, et al. Clin Cancer Res, 2003 Nov 1. PMID 14614009
  5. Telomerase as a prognostic marker in breast cancer: high-throughput tissue microarray analysis of hTERT and hTR. Poremba C, et al. J Pathol, 2002 Oct. PMID 12237877

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA polymerase binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to RNA-directed DNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
enables WD40-repeat domain binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to telomerase RNA reverse transcriptase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to telomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables telomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables template for synthesis of G-rich strand of telomere DNA activity ISO
Inferred from Sequence Orthology
more info
  
enables template for synthesis of G-rich strand of telomere DNA activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within determination of adult lifespan ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hematopoietic stem cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hematopoietic stem cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within telomere maintenance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance via telomerase TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
  
part_of box H/ACA telomerase RNP complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of telomerase catalytic core complex ISO
Inferred from Sequence Orthology
more info
  
part_of telomerase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_001567.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AF221916

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    114744148..114744535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Chemical Information
Molecular Biology Databases