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ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 [ Homo sapiens (human) ]

Gene ID: 377841, updated on 1-Aug-2020

Summary

Official Symbol
ENTPD8provided by HGNC
Official Full Name
ectonucleoside triphosphate diphosphohydrolase 8provided by HGNC
Primary source
HGNC:HGNC:24860
See related
Ensembl:ENSG00000188833 MIM:616748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNQ2492; GLSR2492; E-NTPDase; NTPDase-8
Expression
Biased expression in colon (RPKM 14.4), duodenum (RPKM 11.4) and 6 other tissues See more
Orthologs

Genomic context

See ENTPD8 in Genome Data Viewer
Location:
9q34.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (137434364..137441710, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (140328816..140335901, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene NOTCH regulated ankyrin repeat protein Neighboring gene exonuclease 3'-5' domain containing 3 Neighboring gene NADPH oxidase activator 1 Neighboring gene microRNA 7114 Neighboring gene NMDA receptor synaptonuclear signaling and neuronal migration factor Neighboring gene patatin like phospholipase domain containing 7 Neighboring gene 9q34.3 PNPLA7 recombination region

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
8-oxo-dGTP phosphohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GTP phosphohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
dATP phosphohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
dCTP phosphohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
dGTP phosphohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
dTTP phosphohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
dUTP phosphohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleoside-diphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
nucleoside-triphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
nucleobase-containing small molecule catabolic process TAS
Traceable Author Statement
more info
 
nucleoside diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
nucleoside monophosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ectonucleoside triphosphate diphosphohydrolase 8
Names
E-NTPDase 8
liver ecto-ATP-diphosphohydrolase
NP_001028285.1
NP_940987.2
XP_011516967.1
XP_011516968.1
XP_011516970.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033113.2NP_001028285.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform 1

    See identical proteins and their annotated locations for NP_001028285.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform.
    Source sequence(s)
    BX322799
    Consensus CDS
    CCDS43913.1
    UniProtKB/Swiss-Prot
    Q5MY95
    Related
    ENSP00000360561.2, ENST00000371506.6
    Conserved Domains (1) summary
    cl17037
    Location:34459
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. NM_198585.3NP_940987.2  ectonucleoside triphosphate diphosphohydrolase 8 isoform 2

    See identical proteins and their annotated locations for NP_940987.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AY359088, BX322799
    Consensus CDS
    CCDS7043.1
    UniProtKB/Swiss-Prot
    Q5MY95
    Related
    ENSP00000344089.2, ENST00000344119.6
    Conserved Domains (1) summary
    cl17037
    Location:34422
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    137434364..137441710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518666.2XP_011516968.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X2

    Conserved Domains (1) summary
    cl17037
    Location:142530
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. XM_011518665.2XP_011516967.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X1

    Related
    ENST00000461823.1
    Conserved Domains (1) summary
    cl17037
    Location:142567
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  3. XM_011518668.1XP_011516970.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X3

    See identical proteins and their annotated locations for XP_011516970.1

    Conserved Domains (1) summary
    cl17037
    Location:1332
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
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