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USP17L2 ubiquitin specific peptidase 17 like family member 2 [ Homo sapiens (human) ]

Gene ID: 377630, updated on 13-May-2022

Summary

Official Symbol
USP17L2provided by HGNC
Official Full Name
ubiquitin specific peptidase 17 like family member 2provided by HGNC
Primary source
HGNC:HGNC:34434
See related
Ensembl:ENSG00000223443 MIM:610186; AllianceGenome:HGNC:34434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DUB3; DUB-3; USP17
Summary
DUB3 is a member of the ubiquitin processing protease (UBP) subfamily of deubiquitinating enzymes. See USP1 (MIM 603478) for background information.[supplied by OMIM, Mar 2008]
Annotation information
Annotation category: suggests misassembly
Orthologs
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Genomic context

See USP17L2 in Genome Data Viewer
Location:
8p23.1
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (12136435..12138849, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (7595654..7598068)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (11993944..11996358, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 66 member D Neighboring gene ubiquitin specific peptidase 17 like family member 2 pseudogene Neighboring gene ubiquitin specific peptidase 17 like family member 7 Neighboring gene defensin beta 109D (pseudogene) Neighboring gene family with sequence similarity 90 member A2, pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type deubiquitinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cysteine-type deubiquitinase activity TAS
Traceable Author Statement
more info
 
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in CAAX-box protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in MAPK cascade TAS
Traceable Author Statement
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of histone deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of MDA-5 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of RIG-I signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein K48-linked deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein K63-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K63-linked deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deubiquitination TAS
Traceable Author Statement
more info
 
involved_in regulation of G2/MI transition of meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of ruffle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 17
Names
deubiquitinating enzyme 17-like protein 2
deubiquitinating enzyme 3
deubiquitinating protein 3
ubiquitin carboxyl-terminal hydrolase 17-like protein 2
ubiquitin specific peptidase 17-like 2
ubiquitin thioesterase 17-like protein 2
ubiquitin thiolesterase 17-like protein 2
ubiquitin-specific-processing protease 17-like protein 2
NP_958804.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201402.3NP_958804.2  ubiquitin carboxyl-terminal hydrolase 17

    See identical proteins and their annotated locations for NP_958804.2

    Status: VALIDATED

    Source sequence(s)
    AC130366
    Consensus CDS
    CCDS43713.1
    UniProtKB/Swiss-Prot
    Q6R6M4
    Related
    ENSP00000333329.3, ENST00000333796.4
    Conserved Domains (3) summary
    cd02661
    Location:79373
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:80372
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam04774
    Location:426454
    HABP4_PAI-RBP1; Hyaluronan / mRNA binding family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    12136435..12138849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    7595654..7598068
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)