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ARF3 ADP ribosylation factor 3 [ Homo sapiens (human) ]

Gene ID: 377, updated on 7-Jun-2020

Summary

Official Symbol
ARF3provided by HGNC
Official Full Name
ADP ribosylation factor 3provided by HGNC
Primary source
HGNC:HGNC:654
See related
Ensembl:ENSG00000134287 MIM:103190
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. The ARF3 gene contains five exons and four introns. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 69.0), colon (RPKM 28.8) and 24 other tissues See more
Orthologs

Genomic context

See ARF3 in Genome Data Viewer
Location:
12q13.12
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (48930252..48957526, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (49329987..49351309, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 65 Neighboring gene FKBP prolyl isomerase 11 Neighboring gene Wnt family member 10B Neighboring gene RNA, U6 small nuclear 940, pseudogene Neighboring gene uncharacterized LOC105369757 Neighboring gene Wnt family member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
 
retrograde vesicle-mediated transport, Golgi to ER IGI
Inferred from Genetic Interaction
more info
PubMed 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ADP-ribosylation factor 3
Names
small GTP binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001659.3NP_001650.1  ADP-ribosylation factor 3

    See identical proteins and their annotated locations for NP_001650.1

    Status: REVIEWED

    Source sequence(s)
    AC073610
    Consensus CDS
    CCDS8774.1
    UniProtKB/Swiss-Prot
    P61204
    UniProtKB/TrEMBL
    A0A024R0Y6
    Related
    ENSP00000256682.4, ENST00000256682.9
    Conserved Domains (1) summary
    cl21455
    Location:5179
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    48930252..48957526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719391.4XP_006719454.1  ADP-ribosylation factor 3 isoform X2

    Conserved Domains (2) summary
    COG1100
    Location:15128
    Gem1; GTPase SAR1 family domain [General function prediction only]
    cl21455
    Location:1128
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_005268856.1XP_005268913.1  ADP-ribosylation factor 3 isoform X1

    See identical proteins and their annotated locations for XP_005268913.1

    UniProtKB/Swiss-Prot
    P61204
    UniProtKB/TrEMBL
    A0A024R0Y6
    Conserved Domains (1) summary
    cl21455
    Location:5179
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_024448972.1XP_024304740.1  ADP-ribosylation factor 3 isoform X1

    Conserved Domains (1) summary
    cl21455
    Location:5179
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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