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Fbxo42 F-box protein 42 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37532, updated on 26-Apr-2024

Summary

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Official Symbol
Fbxo42provided by FlyBase
Official Full Name
F-box protein 42provided by FlyBase
Primary source
FLYBASE:FBgn0034704
Locus tag
Dmel_CG6758
See related
AllianceGenome:FB:FBgn0034704
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6758; Dmel\CG6758; FBXO6
Summary
Enables ubiquitin ligase-substrate adaptor activity. Involved in positive regulation of synaptonemal complex assembly. Part of SCF ubiquitin ligase complex. Orthologous to human FBXO42 (F-box protein 42). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
58C5-58C5; 2-98 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22174922..22177428)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18062427..18064933)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene arc Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45151 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FipoQ/FBXO33, a Cullin-1-based ubiquitin ligase complex component modulates ubiquitination and solubility of polyglutamine disease protein. Chen ZS, et al. J Neurochem, 2019 Jun. PMID 30685895
  2. SCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56. Barbosa P, et al. J Cell Biol, 2021 Feb 1. PMID 33382409, Free PMC Article
  3. A conserved F-box gene with unusual transcript localization. Das T, et al. Dev Genes Evol, 2002 Apr. PMID 11976951
  4. F-box proteins: the key to protein degradation. Ho MS, et al. J Biomed Sci, 2006 Mar. PMID 16463014
  5. A systematic phenotypic screen of F-box genes through a tissue-specific RNAi-based approach in Drosophila. Dui W, et al. J Genet Genomics, 2012 Aug 20. PMID 22884096

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like ligase-substrate adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISM
Inferred from Sequence Model
more info
  
involved_in positive regulation of synaptonemal complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SCF ubiquitin ligase complex ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
F-box protein 42
Names
CG6758-PA
Fbxo42-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    22174922..22177428
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137803.3 → NP_611647.1  F-box protein 42 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611647.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W281
    Related
    FBpp0071681
    Conserved Domains (4) summary
    sd00038
    Location:103 → 148
    Kelch; KELCH repeat [structural motif]
    pfam12937
    Location:24 → 59
    F-box-like; F-box-like
    pfam13415
    Location:112 → 162
    Kelch_3; Galactose oxidase, central domain
    pfam13854
    Location:209 → 249
    Kelch_5; Kelch motif
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W281 Q9W281

Gene LinkOut

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