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LINC01116 long intergenic non-protein coding RNA 1116 [ Homo sapiens (human) ]

Gene ID: 375295, updated on 25-Nov-2025
Official Symbol
LINC01116provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 1116provided by HGNC
Primary source
HGNC:HGNC:49259
See related
Ensembl:ENSG00000163364 AllianceGenome:HGNC:49259
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TALNEC2
Expression
Broad expression in ovary (RPKM 6.9), adrenal (RPKM 5.0) and 15 other tissues See more
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See LINC01116 in Genome Data Viewer
Location:
2q31.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (176611437..176637609, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (177093539..177119723, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (177476165..177502337, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124907910 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:177453489-177454688 Neighboring gene microRNA 1246 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:177485641-177486840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12138 Neighboring gene VISTA enhancer hs248 Neighboring gene long intergenic non-protein coding RNA 1117 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12139 Neighboring gene RNA, U6atac small nuclear 14, pseudogene

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LINC01116-dependent upregulation of RNA polymerase I transcription drives oncogenic phenotypes in lung adenocarcinoma.
    Title: LINC01116-dependent upregulation of RNA polymerase I transcription drives oncogenic phenotypes in lung adenocarcinoma.
  2. Linc01116 Silencing Inhibits the Proliferation and Invasion, Promotes Apoptosis of Chordoma Cells via Regulating the Expression of Mir-9-5p/PKG1.
    Title: Linc01116 Silencing Inhibits the Proliferation and Invasion, Promotes Apoptosis of Chordoma Cells via Regulating the Expression of Mir-9-5p/PKG1.
  3. Hypoxia-induced factor-1alpha promotes radioresistance of esophageal cancer cells by transcriptionally activating LINC01116 and suppressing miR-3612 under hypoxia.
    Title: Hypoxia-induced factor-1α promotes radioresistance of esophageal cancer cells by transcriptionally activating LINC01116 and suppressing miR-3612 under hypoxia.
  4. LINC01116 affects patient survival differently and is dissimilarly expressed in ER+ and ER- breast cancer samples.
    Title: LINC01116 affects patient survival differently and is dissimilarly expressed in ER+ and ER- breast cancer samples.
  5. Comprehensive analysis of candidate signatures of long non-coding RNA LINC01116 and related protein-coding genes in patients with hepatocellular carcinoma.
    Title: Comprehensive analysis of candidate signatures of long non-coding RNA LINC01116 and related protein-coding genes in patients with hepatocellular carcinoma.
  6. LINC01116 Regulates the Proliferation and Apoptosis of Nucleus Pulposus Cells through miR-9-5p-mediated ZIC5 and the Wnt Pathway and Affects the Progression of Intervertebral Disc Degeneration.
    Title: LINC01116 Regulates the Proliferation and Apoptosis of Nucleus Pulposus Cells through miR-9-5p-mediated ZIC5 and the Wnt Pathway and Affects the Progression of Intervertebral Disc Degeneration.
  7. LINC01116 modulates EMT process via binding with AGO1 mRNA in oesophageal squamous cell carcinoma.
    Title: LINC01116 modulates EMT process via binding with AGO1 mRNA in oesophageal squamous cell carcinoma.
  8. The mechanism of lncRNA TALNEC2 regulating miR-19a-3p/JNK to alleviate cerebral ischemia injury in rats with acute cerebral infarction.
    Title: The mechanism of lncRNA TALNEC2 regulating miR-19a-3p/JNK to alleviate cerebral ischemia injury in rats with acute cerebral infarction.
  9. LINC01116 boosts the progression of pituitary adenoma via regulating miR-744-5p/HOXB8 pathway.
    Title: LINC01116 boosts the progression of pituitary adenoma via regulating miR-744-5p/HOXB8 pathway.
  10. Silencing LINC01116 suppresses the development of lung adenocarcinoma via the AKT signaling pathway.
    Title: Silencing LINC01116 suppresses the development of lung adenocarcinoma via the AKT signaling pathway.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Markers

Other Names

  • Tumor associated lncRNA expressed in chromosome 2

Clone Names

  • AC017048.3

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_040001.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC017048, KF456744
    Related
    ENST00000703418.1

  2. NR_188021.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC017048, KF456744

  3. NR_188022.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC017048, KF456744
    Related
    ENST00000695928.2

  4. NR_188023.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC017048, KF456744

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    176611437..176637609 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    177093539..177119723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials