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PFN4 profilin family member 4 [ Homo sapiens (human) ]

Gene ID: 375189, updated on 23-Nov-2021

Summary

Official Symbol
PFN4provided by HGNC
Official Full Name
profilin family member 4provided by HGNC
Primary source
HGNC:HGNC:31103
See related
Ensembl:ENSG00000176732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Restricted expression toward testis (RPKM 24.5) See more
Orthologs
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Genomic context

See PFN4 in Genome Data Viewer
Location:
2p23.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (24114809..24124268, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (24337679..24346204, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene FKBP prolyl isomerase 1B Neighboring gene splicing factor 3b subunit 6 Neighboring gene family with sequence similarity 228 member B Neighboring gene tumor protein p53 inducible protein 3 Neighboring gene uncharacterized LOC105374328 Neighboring gene family with sequence similarity 228 member A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin monomer binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in sequestering of actin monomers IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
profilin-4
Names
profilin IV

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199346.3NP_955378.1  profilin-4

    See identical proteins and their annotated locations for NP_955378.1

    Status: VALIDATED

    Source sequence(s)
    AC008073, AK292601
    Consensus CDS
    CCDS1709.1
    UniProtKB/Swiss-Prot
    Q8NHR9
    Related
    ENSP00000322170.4, ENST00000313213.5
    Conserved Domains (1) summary
    cd00148
    Location:14129
    PROF; Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and poly-L-proline. Profilin can inhibit actin polymerization into F-actin by binding to monomeric actin (G-actin) and terminal F-actin subunits, but - as a regulator of the ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    24114809..24124268 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712007.4XP_006712070.1  profilin-4 isoform X1

    See identical proteins and their annotated locations for XP_006712070.1

    UniProtKB/Swiss-Prot
    Q8NHR9
    Conserved Domains (1) summary
    cd00148
    Location:14129
    PROF; Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and poly-L-proline. Profilin can inhibit actin polymerization into F-actin by binding to monomeric actin (G-actin) and terminal F-actin subunits, but - as a regulator of the ...
  2. XM_005264292.2XP_005264349.1  profilin-4 isoform X1

    See identical proteins and their annotated locations for XP_005264349.1

    UniProtKB/Swiss-Prot
    Q8NHR9
    Conserved Domains (1) summary
    cd00148
    Location:14129
    PROF; Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and poly-L-proline. Profilin can inhibit actin polymerization into F-actin by binding to monomeric actin (G-actin) and terminal F-actin subunits, but - as a regulator of the ...
  3. XM_011532823.2XP_011531125.1  profilin-4 isoform X1

    See identical proteins and their annotated locations for XP_011531125.1

    UniProtKB/Swiss-Prot
    Q8NHR9
    Conserved Domains (1) summary
    cd00148
    Location:14129
    PROF; Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and poly-L-proline. Profilin can inhibit actin polymerization into F-actin by binding to monomeric actin (G-actin) and terminal F-actin subunits, but - as a regulator of the ...
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