Format

Send to:

Choose Destination

KCND1 potassium voltage-gated channel subfamily D member 1 [ Homo sapiens (human) ]

Gene ID: 3750, updated on 1-Jun-2020

Summary

Official Symbol
KCND1provided by HGNC
Official Full Name
potassium voltage-gated channel subfamily D member 1provided by HGNC
Primary source
HGNC:HGNC:6237
See related
Ensembl:ENSG00000102057 MIM:300281
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KV4.1
Summary
This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type potassium channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, insulin secretion, and smooth muscle contraction. [provided by RefSeq, Aug 2013]
Expression
Ubiquitous expression in gall bladder (RPKM 1.4), brain (RPKM 1.1) and 24 other tissues See more
Orthologs

Genomic context

See KCND1 in Genome Data Viewer
Location:
Xp11.23
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (48960983..48972103, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (48818639..48828251, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene Pim-2 proto-oncogene, serine/threonine kinase Neighboring gene OTU deubiquitinase 5 Neighboring gene RNA, U6 small nuclear 722, pseudogene Neighboring gene GRIP1 associated protein 1 Neighboring gene Sharpr-MPRA regulatory region 9113 Neighboring gene Sharpr-MPRA regulatory region 2669 Neighboring gene transcription factor binding to IGHM enhancer 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
A-type (transient outward) potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cardiac conduction TAS
Traceable Author Statement
more info
 
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
potassium voltage-gated channel subfamily D member 1
Names
Shal-type potassium channel
potassium channel, voltage gated Shal related subfamily D, member 1
potassium voltage-gated channel, Shal-related subfamily, member 1
voltage-gated potassium channel subunit Kv4.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012515.2 RefSeqGene

    Range
    4996..15460
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004979.6NP_004970.3  potassium voltage-gated channel subfamily D member 1 precursor

    See identical proteins and their annotated locations for NP_004970.3

    Status: REVIEWED

    Source sequence(s)
    AC233294, AJ005898, AK094431, BC045659
    Consensus CDS
    CCDS14314.1
    UniProtKB/Swiss-Prot
    Q9NSA2
    Related
    ENSP00000218176.3, ENST00000218176.4
    Conserved Domains (4) summary
    pfam11601
    Location:328
    Shal-type; Shal-type voltage-gated potassium channels, N-terminal
    pfam00520
    Location:185417
    Ion_trans; Ion transport protein
    pfam02214
    Location:42131
    BTB_2; BTB/POZ domain
    pfam11879
    Location:447550
    DUF3399; Domain of unknown function (DUF3399)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    48960983..48972103 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452378.1XP_024308146.1  potassium voltage-gated channel subfamily D member 1 isoform X1

    Conserved Domains (4) summary
    pfam11601
    Location:328
    Shal-type; Shal-type voltage-gated potassium channels, N-terminal
    pfam00520
    Location:185417
    Ion_trans; Ion transport protein
    pfam02214
    Location:42131
    BTB_2; BTB/POZ domain
    pfam11879
    Location:447578
    DUF3399; Domain of unknown function (DUF3399)
  2. XM_011543910.2XP_011542212.1  potassium voltage-gated channel subfamily D member 1 isoform X2

    See identical proteins and their annotated locations for XP_011542212.1

    UniProtKB/Swiss-Prot
    Q9NSA2
    Conserved Domains (4) summary
    pfam11601
    Location:328
    Shal-type; Shal-type voltage-gated potassium channels, N-terminal
    pfam00520
    Location:185417
    Ion_trans; Ion transport protein
    pfam02214
    Location:42131
    BTB_2; BTB/POZ domain
    pfam11879
    Location:447550
    DUF3399; Domain of unknown function (DUF3399)
  3. XM_017029509.1XP_016884998.1  potassium voltage-gated channel subfamily D member 1 isoform X3

  4. XM_017029508.1XP_016884997.1  potassium voltage-gated channel subfamily D member 1 isoform X3

  5. XM_017029510.2XP_016884999.1  potassium voltage-gated channel subfamily D member 1 isoform X4

Support Center