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IGFL1 IGF like family member 1 [ Homo sapiens (human) ]

Gene ID: 374918, updated on 25-Jan-2022

Summary

Official Symbol
IGFL1provided by HGNC
Official Full Name
IGF like family member 1provided by HGNC
Primary source
HGNC:HGNC:24093
See related
Ensembl:ENSG00000188293 MIM:610544; AllianceGenome:HGNC:24093
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNQ644; APRG644
Summary
The protein encoded by this gene is a member of the insulin-like growth factor family of signaling molecules. The encoded protein is synthesized as a precursor protein and is proteolytically cleaved to form a secreted mature peptide. The mature peptide binds to a receptor, which in mouse was found on the cell surface of T cells. Increased expression of this gene may be linked to psoriasis. [provided by RefSeq, Aug 2016]
Expression
Restricted expression toward esophagus (RPKM 30.9) See more
Orthologs
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Genomic context

See IGFL1 in Genome Data Viewer
Location:
19q13.32
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (46229742..46231243)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46732999..46734500)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene IGF like family member 2 Neighboring gene uncharacterized LOC93429 Neighboring gene ribosomal protein L12 pseudogene 41 Neighboring gene Sharpr-MPRA regulatory region 13463 Neighboring gene IGF like family member 1 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
insulin growth factor-like family member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198541.2NP_940943.1  insulin growth factor-like family member 1 precursor

    See identical proteins and their annotated locations for NP_940943.1

    Status: REVIEWED

    Source sequence(s)
    AC006262, AY359013
    Consensus CDS
    CCDS46123.1
    UniProtKB/Swiss-Prot
    Q6UW32
    Related
    ENSP00000415823.1, ENST00000437936.2
    Conserved Domains (1) summary
    pfam14653
    Location:3486
    IGFL; Insulin growth factor-like family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    46229742..46231243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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