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ASPG asparaginase [ Homo sapiens (human) ]

Gene ID: 374569, updated on 26-Sep-2020

Summary

Official Symbol
ASPGprovided by HGNC
Official Full Name
asparaginaseprovided by HGNC
Primary source
HGNC:HGNC:20123
See related
Ensembl:ENSG00000166183 MIM:618472
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPA/WT; LYSOLP; C14orf76
Expression
Biased expression in liver (RPKM 7.5), kidney (RPKM 3.8) and 8 other tissues See more
Orthologs

Genomic context

See ASPG in Genome Data Viewer
Location:
14q32.33
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (104085658..104115582)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (104552019..104579100)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene tudor domain containing 9 Neighboring gene retinal degeneration 3 like Neighboring gene RNA, 7SL, cytoplasmic 634, pseudogene Neighboring gene microRNA 203a Neighboring gene microRNA 203b Neighboring gene uncharacterized LOC105370708

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
An atlas of genetic influences on human blood metabolites.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-alkyl-2-acetylglycerophosphocholine esterase activity IEA
Inferred from Electronic Annotation
more info
 
asparaginase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
asparaginase activity TAS
Traceable Author Statement
more info
 
lysophospholipase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidyl phospholipase B activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity, transferring acyl groups other than amino-acyl groups ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cellular amino acid biosynthetic process TAS
Traceable Author Statement
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
60 kDa lysophospholipase
Names
asparaginase homolog
lysophospholipase-transacylase
wild-type L-asparaginase
NP_001073933.2
XP_005267647.1
XP_016876754.1
XP_016876755.1
XP_016876756.1
XP_016876757.1
XP_016876758.1
XP_016876759.1
XP_016876760.1
XP_016876761.1
XP_016876762.1
XP_016876763.1
XP_016876764.1
XP_016876765.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080464.3NP_001073933.2  60 kDa lysophospholipase

    See identical proteins and their annotated locations for NP_001073933.2

    Status: VALIDATED

    Source sequence(s)
    AL136001, AW024833, BC136637, BM544197, BX280385, BX407951
    Consensus CDS
    CCDS45170.2
    UniProtKB/Swiss-Prot
    Q86U10
    Related
    ENSP00000450040.1, ENST00000551177.6
    Conserved Domains (4) summary
    PTZ00322
    Location:504553
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    sd00045
    Location:433464
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:408496
    Ank_2; Ankyrin repeats (3 copies)
    cl00216
    Location:9361
    L-asparaginase_like; Bacterial L-asparaginases and related enzymes

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    104085658..104115582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021268.1XP_016876757.1  60 kDa lysophospholipase isoform X4

  2. XM_005267590.4XP_005267647.1  60 kDa lysophospholipase isoform X13

    See identical proteins and their annotated locations for XP_005267647.1

    UniProtKB/Swiss-Prot
    Q86U10
    Related
    ENSP00000448911.2, ENST00000546892.6
    Conserved Domains (5) summary
    cd00204
    Location:407553
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:408496
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:503553
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:433464
    ANK; ANK repeat [structural motif]
    cl00216
    Location:9361
    L-asparaginase_like; Bacterial L-asparaginases and related enzymes
  3. XM_017021274.1XP_016876763.1  60 kDa lysophospholipase isoform X10

  4. XM_017021266.1XP_016876755.1  60 kDa lysophospholipase isoform X2

  5. XM_017021267.1XP_016876756.1  60 kDa lysophospholipase isoform X3

  6. XM_017021272.1XP_016876761.1  60 kDa lysophospholipase isoform X8

  7. XM_017021273.1XP_016876762.1  60 kDa lysophospholipase isoform X9

  8. XM_017021275.1XP_016876764.1  60 kDa lysophospholipase isoform X11

  9. XM_017021276.1XP_016876765.1  60 kDa lysophospholipase isoform X12

  10. XM_017021265.1XP_016876754.1  60 kDa lysophospholipase isoform X1

  11. XM_017021270.1XP_016876759.1  60 kDa lysophospholipase isoform X6

  12. XM_017021271.1XP_016876760.1  60 kDa lysophospholipase isoform X7

  13. XM_017021269.1XP_016876758.1  60 kDa lysophospholipase isoform X5

RNA

  1. XR_001750304.1 RNA Sequence

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