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D1R temporal expression: early [ Vaccinia virus ]

Gene ID: 3707562, updated on 18-Aug-2023

Summary

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Gene symbol
D1R
Gene description
temporal expression: early
Locus tag
VACWR106
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Vaccinia virus (strain: WR (Western Reserve))
Lineage
Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae; Orthopoxvirus
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Genomic context

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Sequence:
NC_006998.1 (93948..96482)

NC_006998.1Genomic Context describing neighboring genes Neighboring gene DNA topoisomerase type I Neighboring gene temporal expression: late Neighboring gene temporal expression: late Neighboring gene temporal expression: late Neighboring gene temporal expression: early

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_006998.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of vaccinia termination factor and cis-acting elements in vaccinia virus early gene transcription termination. Tate J, et al. Virology, 2015 Nov. PMID 26280468
  2. Crystal structure of vaccinia virus mRNA capping enzyme provides insights into the mechanism and evolution of the capping apparatus. Kyrieleis OJ, et al. Structure, 2014 Mar 4. PMID 24607143, Free PMC Article
  3. Phenotypic analysis of a temperature sensitive mutant in the large subunit of the vaccinia virus mRNA capping enzyme. Shatzer AN, et al. Virology, 2008 May 25. PMID 18295814, Free PMC Article
  4. Effect of UTP sugar and base modifications on vaccinia virus early gene transcription. Mohamed MR, et al. Virology, 2006 Jun 5. PMID 16460779

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. VTF provides the connection between the termination signal in the RNA transcript and viral RNA polymerase to initiate transcription termination.
    Title: The role of vaccinia termination factor and cis-acting elements in vaccinia virus early gene transcription termination.
  2. Crystal structure of vaccinia virus mRNA capping enzyme
    Title: Crystal structure of vaccinia virus mRNA capping enzyme provides insights into the mechanism and evolution of the capping apparatus.
  3. the results presented in this study provide the first in vivo evidence that the vaccinia virus mRNA capping enzyme plays a role in early gene transcription termination and intermediate gene transcription.
    Title: Phenotypic analysis of a temperature sensitive mutant in the large subunit of the vaccinia virus mRNA capping enzyme.
  4. These results suggest that VTF may play a subtle role in early gene transcription elongation in addition to its known function in mRNA cap formation, early gene transcription termination and intermediate gene transcription initiation.
    Title: Effect of UTP sugar and base modifications on vaccinia virus early gene transcription.
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General gene information

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Homology

General protein information

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Preferred Names
large subunit of mRNA capping enzyme
YP_232988.1
  • similar to VACCP-D1R; transcription termination factor VTF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_006998.1 Reference assembly

    Range
    93948..96482
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_232988.1 large subunit of mRNA capping enzyme [Vaccinia virus]

    See identical proteins and their annotated locations for YP_232988.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P04298, Q76ZS6
    UniProtKB/TrEMBL
    A0A2I2MC43, H2DX40, V5QZK6
    Conserved Domains (2) summary
    pfam03291
    Location:568 → 844
    Pox_MCEL; mRNA capping enzyme
    pfam10640
    Location:28 → 338
    Pox_ATPase-GT; mRNA capping enzyme N-terminal, ATPase and guanylyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
4CKB_A.1
4CKB_D.1
4CKC_A.1
4CKC_D.1
4CKE_A.1
4CKE_D.1
AAO89385.1

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