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Nup188 Nucleoporin 188kDa [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36397, updated on 18-Sep-2024

Summary

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Official Symbol
Nup188provided by FlyBase
Official Full Name
Nucleoporin 188kDaprovided by FlyBase
Primary source
FLYBASE:FBgn0033766
Locus tag
Dmel_CG8771
See related
AllianceGenome:FB:FBgn0033766
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8771; Dmel\CG8771; nup188
Summary
Predicted to be a structural constituent of nuclear pore. Predicted to be involved in nuclear pore organization. Predicted to be part of nuclear pore inner ring. Is expressed in adult head. Orthologous to human NUP188 (nucleoporin 188). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
49B12-49B12; 2-67 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12679967..12686179, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8567472..8573684, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene no extended memory Neighboring gene Glutaminase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Odorant-binding protein 49a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bi-allelic Loss-of-Function Variants in NUP188 Cause a Recognizable Syndrome Characterized by Neurologic, Ocular, and Cardiac Abnormalities. Muir AM, et al. Am J Hum Genet, 2020 May 7. PMID 32275884, Free PMC Article
  2. A single-molecule localization microscopy method for tissues reveals nonrandom nuclear pore distribution in Drosophila. Cheng J, et al. J Cell Sci, 2021 Dec 15. PMID 34806753, Free PMC Article
  3. A screen for genes expressed in the olfactory organs of Drosophila melanogaster identifies genes involved in olfactory behaviour. Tunstall NE, et al. PLoS One, 2012. PMID 22530061, Free PMC Article
  4. dCas9-targeted locus-specific protein isolation method identifies histone gene regulators. Tsui C, et al. Proc Natl Acad Sci U S A, 2018 Mar 20. PMID 29507191, Free PMC Article
  5. Nuclear Pores Assemble from Nucleoporin Condensates During Oogenesis. Hampoelz B, et al. Cell, 2019 Oct 17. PMID 31626769, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of nuclear pore ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in RNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear pore organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of nuclear pore inner ring IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore inner ring ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
nucleoporin 188kDa
Names
CG8771-PB
CG8771-PC
Nup188-PB
Nup188-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12679967..12686179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136966.4 → NP_610810.2  nucleoporin 188kDa, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610810.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z945
    Conserved Domains (1) summary
    pfam10487
    Location:31 → 943
    Nup188; Nucleoporin subcomplex protein binding to Pom34

  2. NM_001259354.2 → NP_001246283.1  nucleoporin 188kDa, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246283.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4K859, A1Z945
    Conserved Domains (1) summary
    cl29134
    Location:31 → 943
    Nup188; Nucleoporin subcomplex protein binding to Pom34
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K859.1 A0A0B4K859

Gene LinkOut

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