Lars2 leucyl-tRNA synthetase 2, mitochondrial [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lars2provided by RGD
Official Full Name: leucyl-tRNA synthetase 2, mitochondrialprovided by RGD
Primary source: RGD:1308429
See related: EnsemblRapid:ENSRNOG00000004760 AllianceGenome:RGD:1308429
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable leucine-tRNA ligase activity. Predicted to be involved in leucyl-tRNA aminoacylation and mitochondrial translation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human LARS2 (leucyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 101.9), Muscle (RPKM 83.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (131887728..131983866)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (123010271..123106395)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (132441277..132537176)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BE110407 (e-PCR)
- UniSTS:245253

D8Rat192 (e-PCR)
- UniSTS:239395

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA editing activity	IEA Inferred from Electronic Annotation more info
enables leucine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables leucine-tRNA ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in aminoacyl-tRNA metabolism involved in translational fidelity	IEA Inferred from Electronic Annotation more info
involved_in leucyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in leucyl-tRNA aminoacylation	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial translation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: leucine--tRNA ligase, mitochondrial

Names: leucyl-tRNA synthetase, mitochondrial; probable leucine--tRNA ligase, mitochondrial; probable leucyl-tRNA synthetase, mitochondrial

NP_001400771.1

EC 6.1.1.4

XP_008764949.1

EC 6.1.1.4

XP_063121930.1

EC 6.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001413842.1 → NP_001400771.1 leucine--tRNA ligase, mitochondrial

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I5ZU78

Related

ENSRNOP00000082486.1, ENSRNOT00000101297.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

131887728..131983866

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063265860.1 → XP_063121930.1 leucine--tRNA ligase, mitochondrial isoform X2
XM_008766727.4 → XP_008764949.1 leucine--tRNA ligase, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A0G2K9E5, A0A8I6G2M3

Related

ENSRNOP00000074967.2, ENSRNOT00000087488.3

Conserved Domains (4) summary

cd07958
Location:626 → 751

Anticodon_Ia_Leu_BEm; Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases

cd00812
Location:82 → 626

LeuRS_core; catalytic core domain of leucyl-tRNA synthetases

PRK00390
Location:56 → 850

leuS; leucyl-tRNA synthetase; Validated

pfam13603
Location:219 → 378

tRNA-synt_1_2; Leucyl-tRNA synthetase, Domain 2