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Gpsm2 G-protein signaling modulator 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362021, updated on 2-May-2024

Summary

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Official Symbol
Gpsm2provided by RGD
Official Full Name
G-protein signaling modulator 2provided by RGD
Primary source
RGD:1560967
See related
Ensembl:ENSRNOG00000012149 AllianceGenome:RGD:1560967
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560967
Summary
Predicted to enable several functions, including G-protein alpha-subunit binding activity; dynein complex binding activity; and protein C-terminus binding activity. Predicted to be involved in several processes, including Ran protein signal transduction; maintenance of centrosome location; and regulation of spindle organization. Predicted to act upstream of or within establishment of mitotic spindle orientation and lung epithelial cell differentiation. Predicted to be located in several cellular components, including apical part of cell; centrosome; and lateral cell cortex. Predicted to be part of protein-containing complex. Predicted to colocalize with cell cortex and mitotic spindle pole. Human ortholog(s) of this gene implicated in sensorineural hearing loss. Orthologous to human GPSM2 (G protein signaling modulator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 66.5), Uterus (RPKM 66.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q34
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (199015250..199063788, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (196327149..196375322, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (211480120..211528096, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 47 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene chloride channel CLIC-like 1 Neighboring gene AKNA domain containing 1 Neighboring gene uncharacterized LOC102547393 Neighboring gene syntaxin binding protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. GPSM2 mutations cause the brain malformations and hearing loss in Chudley-McCullough syndrome. Doherty D, et al. Am J Hum Genet, 2012 Jun 8. PMID 22578326, Free PMC Article
  2. A truncating mutation in GPSM2 is associated with recessive non-syndromic hearing loss. Yariz KO, et al. Clin Genet, 2012 Mar. PMID 21348867, Free PMC Article
  3. Crystal structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Gαi. Jia M, et al. J Biol Chem, 2012 Oct 26. PMID 22952234, Free PMC Article
  4. LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gαi/LGN/NuMA pathways. Zhu J, et al. Mol Cell, 2011 Aug 5. PMID 21816348, Free PMC Article
  5. A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization. Du Q, et al. Nat Cell Biol, 2001 Dec. PMID 11781568

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables GDP-dissociation inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP-dissociation inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables dynein complex binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in establishment of mitotic spindle orientation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within establishment of mitotic spindle orientation ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of mitotic spindle orientation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lung epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of centrosome location ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
  
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein localization to cell cortex ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of spindle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in lateral cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
G-protein-signaling modulator 2
Names
G-protein signaling modulator 2 (AGS3-like, C. elegans)
G-protein signalling modulator 2 (AGS3-like, C. elegans)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191962.1 → NP_001178891.1  G-protein-signaling modulator 2

    See identical proteins and their annotated locations for NP_001178891.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    D3ZCE5
    Conserved Domains (5) summary
    smart00390
    Location:490 → 512
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    COG0457
    Location:27 → 286
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:243 → 270
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:243 → 314
    TPR_12; Tetratricopeptide repeat
    pfam02188
    Location:594 → 613
    GoLoco; GoLoco motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    199015250..199063788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008761411.3 → XP_008759633.1  G-protein-signaling modulator 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AGM3
    Related
    ENSRNOP00000092477.1
    Conserved Domains (5) summary
    smart00390
    Location:471 → 493
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    COG0457
    Location:8 → 267
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:224 → 251
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:224 → 295
    TPR_12; Tetratricopeptide repeat
    pfam02188
    Location:575 → 594
    GoLoco; GoLoco motif

  2. XM_008761409.3 → XP_008759631.1  G-protein-signaling modulator 2 isoform X1

    See identical proteins and their annotated locations for XP_008759631.1

    UniProtKB/TrEMBL
    D3ZCE5
    Related
    ENSRNOP00000062330.2
    Conserved Domains (5) summary
    smart00390
    Location:490 → 512
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    COG0457
    Location:27 → 286
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:243 → 270
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:243 → 314
    TPR_12; Tetratricopeptide repeat
    pfam02188
    Location:594 → 613
    GoLoco; GoLoco motif

  3. XM_039102710.2 → XP_038958638.1  G-protein-signaling modulator 2 isoform X1

    UniProtKB/TrEMBL
    D3ZCE5
    Conserved Domains (5) summary
    smart00390
    Location:490 → 512
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    COG0457
    Location:27 → 286
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:243 → 270
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:243 → 314
    TPR_12; Tetratricopeptide repeat
    pfam02188
    Location:594 → 613
    GoLoco; GoLoco motif

  4. XM_039102712.2 → XP_038958640.1  G-protein-signaling modulator 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AGM3
    Conserved Domains (5) summary
    smart00390
    Location:471 → 493
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    COG0457
    Location:8 → 267
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:224 → 251
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:224 → 295
    TPR_12; Tetratricopeptide repeat
    pfam02188
    Location:575 → 594
    GoLoco; GoLoco motif
Nucleotide Protein Strain
Heading Accession and Version

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