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AQP5 aquaporin 5 [ Homo sapiens (human) ]

Gene ID: 362, updated on 5-Aug-2018

Summary

Official Symbol
AQP5provided by HGNC
Official Full Name
aquaporin 5provided by HGNC
Primary source
HGNC:HGNC:638
See related
Ensembl:ENSG00000161798 MIM:600442; Vega:OTTHUMG00000169710
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPKB; AQP-5
Summary
Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. [provided by RefSeq, Jul 2008]
Expression
Biased expression in salivary gland (RPKM 99.1), testis (RPKM 61.9) and 1 other tissue See more
Orthologs

Genomic context

See AQP5 in Genome Data Viewer
Location:
12q13.12
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (49961496..49965682)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (50355279..50359465)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369763 Neighboring gene uncharacterized LOC101927318 Neighboring gene aquaporin 2 Neighboring gene uncharacterized LOC105369764 Neighboring gene uncharacterized LOC102723963 Neighboring gene aquaporin 6 Neighboring gene Rac GTPase activating protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
water channel activity EXP
Inferred from Experiment
more info
PubMed 
water channel activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
camera-type eye morphogenesis IEA
Inferred from Electronic Annotation
more info
 
carbon dioxide transport IDA
Inferred from Direct Assay
more info
PubMed 
excretion TAS
Traceable Author Statement
more info
PubMed 
odontogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
pancreatic juice secretion IEP
Inferred from Expression Pattern
more info
PubMed 
saliva secretion IEA
Inferred from Electronic Annotation
more info
 
water transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basal plasma membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
microvillus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033883.1 RefSeqGene

    Range
    5001..9187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001651.3NP_001642.1  aquaporin-5

    See identical proteins and their annotated locations for NP_001642.1

    Status: REVIEWED

    Source sequence(s)
    AC025154, BC032946, BP272197, BX095029
    Consensus CDS
    CCDS8793.1
    UniProtKB/Swiss-Prot
    P55064
    Related
    ENSP00000293599.5, OTTHUMP00000241927, ENST00000293599.6, OTTHUMT00000405542
    Conserved Domains (1) summary
    pfam00230
    Location:4221
    MIP; Major intrinsic protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    49961496..49965682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268838.2XP_005268895.1  aquaporin-5 isoform X1

    See identical proteins and their annotated locations for XP_005268895.1

    Conserved Domains (1) summary
    cl00200
    Location:4204
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
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