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Eps8l1 EPS8 signaling adaptor L1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361503, updated on 11-Jun-2025
Official Symbol
Eps8l1provided by RGD
Official Full Name
EPS8 signaling adaptor L1provided by RGD
Primary source
RGD:1311146
See related
Ensembl:ENSRNOG00000027942 AllianceGenome:RGD:1311146
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable T cell receptor binding activity and actin binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in Rho protein signal transduction; positive regulation of ruffle assembly; and regulation of Rho protein signal transduction. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Predicted to be active in ruffle membrane. Orthologous to human EPS8L1 (EPS8 signaling adaptor L1). [provided by Alliance of Genome Resources, Jun 2025]
Expression
Biased expression in Lung (RPKM 114.4), Kidney (RPKM 23.7) and 3 other tissues See more
Orthologs
human mouse all
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See Eps8l1 in Genome Data Viewer
Location:
1q12
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (78386916..78409972, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (69343202..69359778, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (72926106..72942433, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene troponin T1, slow skeletal type Neighboring gene protein phosphatase 1, regulatory subunit 12C Neighboring gene retinol dehydrogenase 13 Neighboring gene glycoprotein VI

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon. Kesti T, et al. J Immunol, 2007 Jul 15. PMID 17617578
  2. MALS is a binding partner of IRSp53 at cell-cell contacts. Hori K, et al. FEBS Lett, 2003 Nov 6. PMID 14596909
  3. The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway. Offenhäuser N, et al. Mol Biol Cell, 2004 Jan. PMID 14565974, Free PMC Article
  4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables T cell receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables T cell receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ruffle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ruffle assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ruffle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in ruffle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
epidermal growth factor receptor kinase substrate 8-like protein 1
Names
EPS8-like 1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108467.2 → NP_001101937.1  epidermal growth factor receptor kinase substrate 8-like protein 1

    See identical proteins and their annotated locations for NP_001101937.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6KNL4, D3ZDV2
    Related
    ENSRNOP00000095614.1, ENSRNOT00000105965.2
    Conserved Domains (4) summary
    cd09540
    Location:623 → 688
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:482 → 534
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    COG5373
    Location:159 → 244
    COG5373; Uncharacterized membrane protein [Function unknown]
    cd01210
    Location:32 → 162
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  2. NM_001437591.1 → NP_001424520.1  epidermal growth factor receptor kinase substrate 8-like protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6KNL4, D3ZDV2

  3. NM_001437592.1 → NP_001424521.1  epidermal growth factor receptor kinase substrate 8-like protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6KNL4, D3ZDV2

  4. NM_001437593.1 → NP_001424522.1  epidermal growth factor receptor kinase substrate 8-like protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6KNL4, D3ZDV2

  5. NM_001437594.1 → NP_001424523.1  epidermal growth factor receptor kinase substrate 8-like protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6KNL4, D3ZDV2

RNA

  1. NR_199362.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    78386916..78409972 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081494.2 → XP_038937422.1  epidermal growth factor receptor kinase substrate 8-like protein 1 isoform X1

    Conserved Domains (4) summary
    cd09540
    Location:623 → 688
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:482 → 534
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    COG5373
    Location:159 → 244
    COG5373; Uncharacterized membrane protein [Function unknown]
    cd01210
    Location:32 → 162
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  2. XM_006228280.4 → XP_006228342.1  epidermal growth factor receptor kinase substrate 8-like protein 1 isoform X1

    Conserved Domains (4) summary
    cd09540
    Location:623 → 688
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:482 → 534
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    COG5373
    Location:159 → 244
    COG5373; Uncharacterized membrane protein [Function unknown]
    cd01210
    Location:32 → 162
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  3. XM_006228278.4 → XP_006228340.1  epidermal growth factor receptor kinase substrate 8-like protein 1 isoform X1

    Conserved Domains (4) summary
    cd09540
    Location:623 → 688
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:482 → 534
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    COG5373
    Location:159 → 244
    COG5373; Uncharacterized membrane protein [Function unknown]
    cd01210
    Location:32 → 162
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  4. XM_008758941.3 → XP_008757163.1  epidermal growth factor receptor kinase substrate 8-like protein 1 isoform X1

    Conserved Domains (4) summary
    cd09540
    Location:623 → 688
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:482 → 534
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    COG5373
    Location:159 → 244
    COG5373; Uncharacterized membrane protein [Function unknown]
    cd01210
    Location:32 → 162
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  5. XM_006228279.4 → XP_006228341.1  epidermal growth factor receptor kinase substrate 8-like protein 1 isoform X1

    Conserved Domains (4) summary
    cd09540
    Location:623 → 688
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:482 → 534
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    COG5373
    Location:159 → 244
    COG5373; Uncharacterized membrane protein [Function unknown]
    cd01210
    Location:32 → 162
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  6. XM_006228282.4 → XP_006228344.1  epidermal growth factor receptor kinase substrate 8-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006228344.1

    UniProtKB/TrEMBL
    A6KNL4, D3ZDV2
    Conserved Domains (4) summary
    cd09540
    Location:623 → 688
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:482 → 534
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    COG5373
    Location:159 → 244
    COG5373; Uncharacterized membrane protein [Function unknown]
    cd01210
    Location:32 → 162
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  7. XM_063266295.1 → XP_063122365.1  epidermal growth factor receptor kinase substrate 8-like protein 1 isoform X2

    UniProtKB/TrEMBL
    D3ZDV2

RNA

  1. XR_350145.5 RNA Sequence

  2. XR_005487826.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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