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Pira2 paired-Ig-like receptor A2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361493, updated on 17-Aug-2024

Summary

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Official Symbol
Pira2provided by RGD
Official Full Name
paired-Ig-like receptor A2provided by RGD
Primary source
RGD:1307219
See related
AllianceGenome:RGD:1307219
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pirb; Lilrb3; Pir-A1; Pir-A2; Lilrb3l
Summary
Predicted to enable inhibitory MHC class I receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 74.0), Lung (RPKM 51.4) and 9 other tissues See more
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Genomic context

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Location:
1q12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (74283713..74338208)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (65352125..65422842)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (63759638..63849278)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin like receptor B2 Neighboring gene uncharacterized LOC120099266 Neighboring gene leukocyte immunoglobulin-like receptor subfamily B member 3-like Neighboring gene small nuclear ribonucleoprotein polypeptide C, pseudogene 4 Neighboring gene constitutive coactivator of PPAR-gamma-like protein 1 Neighboring gene leukocyte immunoglobulin like receptor B1 Neighboring gene paired Ig-like receptor B Neighboring gene ribosomal protein S9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Lipopolysaccharide induces paired immunoglobulin-like receptor B (PirB) expression, synaptic alteration, and learning-memory deficit in rats. Deng XH, et al. Neuroscience, 2012 May 3. PMID 22395112
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results suggest that PirB modulation may be involved in the pathological process under neurodegenerative conditions
    Title: Lipopolysaccharide induces paired immunoglobulin-like receptor B (PirB) expression, synaptic alteration, and learning-memory deficit in rats.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables inhibitory MHC class I receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response-regulating signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
paired-Ig-like receptor A2
Names
Ig-superfamily activating receptor
leukocyte immunoglobulin like receptor B3 like
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like
paired Ig-like receptor-A1
paired Ig-like receptor-B
six Ig-like domains/type I transmembrane

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419491.1 → NP_001406420.1  paired-Ig-like receptor A2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2KAU3, A6KS11, D3ZVK8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    74283713..74338208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266258.1 → XP_063122328.1  paired-Ig-like receptor A2 isoform X3

  2. XM_063266256.1 → XP_063122326.1  paired-Ig-like receptor A2 isoform X1

  3. XM_063266257.1 → XP_063122327.1  paired-Ig-like receptor A2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2KAU3

  4. XM_006228032.4 → XP_006228094.1  paired-Ig-like receptor A2 isoform X4

    UniProtKB/TrEMBL
    A0A0G2KAU3, A0A8I5ZPR5
    Conserved Domains (2) summary
    smart00410
    Location:529 → 616
    IG_like; Immunoglobulin like
    cl11960
    Location:324 → 416
    Ig; Immunoglobulin domain

  5. XM_006228034.4 → XP_006228096.1  paired-Ig-like receptor A2 isoform X5

    Conserved Domains (2) summary
    smart00410
    Location:434 → 521
    IG_like; Immunoglobulin like
    cl11960
    Location:229 → 321
    Ig; Immunoglobulin domain

  6. XM_063266260.1 → XP_063122330.1  paired-Ig-like receptor A2 isoform X6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001037357.2: Suppressed sequence

    Description
    NM_001037357.2: This RefSeq was removed because currently there is insufficient support for the transcript
Nucleotide Protein Strain
Heading Accession and Version

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