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NANOGNB NANOG neighbor homeobox [ Homo sapiens (human) ]

Gene ID: 360030, updated on 6-Jul-2025
Official Symbol
NANOGNBprovided by HGNC
Official Full Name
NANOG neighbor homeoboxprovided by HGNC
Primary source
HGNC:HGNC:24958
See related
Ensembl:ENSG00000205857 MIM:620692; AllianceGenome:HGNC:24958
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Low expression observed in reference dataset See more
Orthologs
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See NANOGNB in Genome Data Viewer
Location:
12p13.31
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (7765216..7774121)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (7779821..7788715)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (7917812..7926717)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene developmental pluripotency associated 3 Neighboring gene MPRA-validated peak1561 silencer Neighboring gene C-type lectin domain family 4 member C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5921 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5922 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:7918923-7919522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:7919523-7920122 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:7924892-7925059 Neighboring gene NANOG 5' regulatory region Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:7950942-7951507 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:7951508-7952074 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:7954393-7954894 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:7957389-7957910 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:7957911-7958430 Neighboring gene Nanog homeobox Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4204 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:7960397-7960896 Neighboring gene solute carrier family 2 member 14 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:7978921-7979457 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:7986285-7986785 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:7991923-7992596 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:7994866-7995750 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:8003712-8004911 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8012389-8013184 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8013185-8013979 Neighboring gene ribosomal protein S20 pseudogene 29

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
NANOG neighbor homeobox
Names
homeobox C14
homeobox protein C14

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145465.1NP_001138937.1  NANOG neighbor homeobox

    See identical proteins and their annotated locations for NP_001138937.1

    Status: VALIDATED

    Source sequence(s)
    AY151139
    Consensus CDS
    CCDS44826.1
    UniProtKB/Swiss-Prot
    Q7Z5D8
    UniProtKB/TrEMBL
    A0A1W2PR93
    Related
    ENSP00000371553.1, ENST00000382119.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    7765216..7774121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    7779821..7788715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)