Tbce Tubulin-binding cofactor E [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tbceprovided by FlyBase
Official Full Name: Tubulin-binding cofactor Eprovided by FlyBase
Primary source: FLYBASE:FBgn0033055
Locus tag: Dmel_CG7861
See related: AllianceGenome:FB:FBgn0033055
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7861; Dmel\CG7861; dTBCE; tbce; TBCE
Summary: Predicted to enable alpha-tubulin binding activity. Involved in microtubule polymerization; neuromuscular synaptic transmission; and regulation of synaptic assembly at neuromuscular junction. Located in cytoplasm. Is expressed in several structures, including embryonic/larval central nervous system; embryonic/larval epidermis; embryonic/larval muscle system; and testis. Used to study hypoparathyroidism-retardation-dysmorphism syndrome. Human ortholog(s) of this gene implicated in Kenny-Caffey syndrome type 1; hypoparathyroidism; and hypoparathyroidism-retardation-dysmorphism syndrome. Orthologous to human TBCE (tubulin folding cofactor E). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 42A8-42A8; 2-55 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (6042532..6044964)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (1930037..1932469)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tubulin-specific chaperone E (TBCE) is required for the normal development and function of neuromuscular synapses and that it promotes microtubule formation
Title: Drosophila Tubulin-specific chaperone E functions at neuromuscular synapses and is required for microtubule network formation.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables alpha-tubulin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule polymerization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in microtubule polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-chaperonin tubulin folding pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tubulin complex assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: Tubulin-binding cofactor E

Names: CG7861-PB; CG7861-PC; Tbce-PB; Tbce-PC; tubulin-specific chaperone E

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

6042532..6044964

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_136353.2 → NP_610197.2 Tubulin-binding cofactor E, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610197.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A1Z6J4, A1Z6J5, Q8MT85

Conserved Domains (3) summary

smart01052
Location:14 → 79

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

sd00033
Location:158 → 183

LRR_RI; leucine-rich repeat [structural motif]

cl26161
Location:148 → 268

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_206025.2 → NP_995747.1 Tubulin-binding cofactor E, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995747.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A1Z6J4, A1Z6J5, Q8MT85

Conserved Domains (3) summary

smart01052
Location:14 → 79

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

sd00033
Location:158 → 183

LRR_RI; leucine-rich repeat [structural motif]

cl26161
Location:148 → 268

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...