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TM9SF2 Transmembrane 9 superfamily protein member 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35335, updated on 18-Sep-2024

Summary

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Official Symbol
TM9SF2provided by FlyBase
Official Full Name
Transmembrane 9 superfamily protein member 2provided by FlyBase
Primary source
FLYBASE:FBgn0032880
Locus tag
Dmel_CG9318
See related
AllianceGenome:FB:FBgn0032880
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
38E.10; CG9318; Dmel\CG9318
Summary
Involved in negative regulation of peptidoglycan recognition protein signaling pathway. Located in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including adult head; embryonic/larval digestive system; extended germ band embryo; germ layer; and presumptive embryonic/larval system. Orthologous to human TM9SF2 (transmembrane 9 superfamily member 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
38E4-38E5; 2-54 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20730416..20734309, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20730416..20734309, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Carcinine transporter Neighboring gene Female sterile (2) Ketel Neighboring gene Alpha-methylacyl-CoA racemase Neighboring gene Nucleostemin 4 Neighboring gene RHAU helicase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The DRE motif is a key component in the expression regulation of the importin-beta encoding Ketel gene in Drosophila. Villanyi Z, et al. Mech Dev, 2008 Sep-Oct. PMID 18656533
  2. The nonaspanins TM9SF2 and TM9SF4 regulate the plasma membrane localization and signalling activity of the peptidoglycan recognition protein PGRP-LC in Drosophila. Perrin J, et al. J Innate Immun, 2015. PMID 25139117, Free PMC Article
  3. Comparative analysis of nonaspanin protein sequences and expression studies in zebrafish. Pruvot B, et al. Immunogenetics, 2010 Oct. PMID 20820770
  4. TM9SF4 is required for Drosophila cellular immunity via cell adhesion and phagocytosis. Bergeret E, et al. J Cell Sci, 2008 Oct 15. PMID 18796536
  5. Map position and expression of the genes in the 38 region of Drosophila. Butler H, et al. Genetics, 2001 Aug. PMID 11514449, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Silencing TM9SF4 prevents plasma membrane localization of PGRP-LC, whereas silencing TM9SF2 does not, which may account for the non-redundant role of TM9SF4 in phagocytosis of Gram-negative bacteria.
    Title: The nonaspanins TM9SF2 and TM9SF4 regulate the plasma membrane localization and signalling activity of the peptidoglycan recognition protein PGRP-LC in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transmembrane 9 superfamily protein member 2
Names
CG9318-PA
CG9318-PB
TM9SF2-PA
TM9SF2-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    20730416..20734309 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273708.1 → NP_001260637.1  transmembrane 9 superfamily protein member 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260637.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VIK1
    Conserved Domains (1) summary
    pfam02990
    Location:64 → 613
    EMP70; Endomembrane protein 70

  2. NM_136209.3 → NP_610053.1  transmembrane 9 superfamily protein member 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610053.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VIK1
    Related
    FBpp0080923
    Conserved Domains (1) summary
    pfam02990
    Location:64 → 613
    EMP70; Endomembrane protein 70
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VIK1 Q9VIK1

Gene LinkOut

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