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GPR141 G protein-coupled receptor 141 [ Homo sapiens (human) ]

Gene ID: 353345, updated on 23-Nov-2021

Summary

Official Symbol
GPR141provided by HGNC
Official Full Name
G protein-coupled receptor 141provided by HGNC
Primary source
HGNC:HGNC:19997
See related
Ensembl:ENSG00000187037 MIM:609045
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR13
Summary
GPR141 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in bone marrow (RPKM 2.2), appendix (RPKM 0.5) and 10 other tissues See more
Orthologs
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Genomic context

See GPR141 in Genome Data Viewer
Location:
7p14.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (37683560..37743835)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (37723369..37783437)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene engulfment and cell motility 1 Neighboring gene ribosomal protein S10 pseudogene 14 Neighboring gene NECAP endocytosis associated 1 pseudogene 1 Neighboring gene G protein-coupled receptor 141B, pseudogene Neighboring gene NME/NM23 family member 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable G-protein coupled receptor 141
Names
G-protein coupled receptor PGR13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329993.2NP_001316922.1  probable G-protein coupled receptor 141

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC083860, AC083865
    Consensus CDS
    CCDS5451.1
    UniProtKB/Swiss-Prot
    Q7Z602
    Conserved Domains (2) summary
    cd14964
    Location:1844
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:17295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. NM_001329994.2NP_001316923.1  probable G-protein coupled receptor 141

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC083860, AC083865
    Consensus CDS
    CCDS5451.1
    UniProtKB/Swiss-Prot
    Q7Z602
    Conserved Domains (2) summary
    cd14964
    Location:1844
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:17295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. NM_001381946.1NP_001368875.1  probable G-protein coupled receptor 141

    Status: REVIEWED

    Source sequence(s)
    AC083860, AC083865
    Related
    ENSP00000334540.1, ENST00000334425.2
    Conserved Domains (2) summary
    cd14964
    Location:1844
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:17295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  4. NM_181791.3NP_861456.1  probable G-protein coupled receptor 141

    See identical proteins and their annotated locations for NP_861456.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variants 2 and 3 all encode the same protein.
    Source sequence(s)
    AC083860, AC083865
    Consensus CDS
    CCDS5451.1
    UniProtKB/Swiss-Prot
    Q7Z602
    Related
    ENSP00000390410.1, ENST00000447769.1
    Conserved Domains (2) summary
    cd14964
    Location:1844
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:17295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    37683560..37743835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515374.3XP_011513676.1  probable G-protein coupled receptor 141 isoform X1

    Conserved Domains (1) summary
    pfam00001
    Location:150393
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. XM_011515375.3XP_011513677.1  probable G-protein coupled receptor 141 isoform X2

    Conserved Domains (1) summary
    pfam00001
    Location:138381
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. XM_017012163.2XP_016867652.1  probable G-protein coupled receptor 141 isoform X4

    Conserved Domains (1) summary
    pfam00001
    Location:66309
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  4. XM_017012166.1XP_016867655.1  probable G-protein coupled receptor 141 isoform X7

    UniProtKB/Swiss-Prot
    Q7Z602
    Conserved Domains (2) summary
    cd14964
    Location:1844
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:17295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  5. XM_017012161.2XP_016867650.1  probable G-protein coupled receptor 141 isoform X3

    Conserved Domains (1) summary
    pfam00001
    Location:92335
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  6. XM_011515389.2XP_011513691.1  probable G-protein coupled receptor 141 isoform X7

    See identical proteins and their annotated locations for XP_011513691.1

    UniProtKB/Swiss-Prot
    Q7Z602
    Conserved Domains (2) summary
    cd14964
    Location:1844
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:17295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  7. XM_017012164.1XP_016867653.1  probable G-protein coupled receptor 141 isoform X5

    Conserved Domains (1) summary
    pfam00001
    Location:43286
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  8. XM_011515388.2XP_011513690.1  probable G-protein coupled receptor 141 isoform X7

    See identical proteins and their annotated locations for XP_011513690.1

    UniProtKB/Swiss-Prot
    Q7Z602
    Conserved Domains (2) summary
    cd14964
    Location:1844
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:17295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  9. XM_011515383.3XP_011513685.1  probable G-protein coupled receptor 141 isoform X6

    Conserved Domains (1) summary
    pfam00001
    Location:43286
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  10. XM_011515386.2XP_011513688.1  probable G-protein coupled receptor 141 isoform X7

    See identical proteins and their annotated locations for XP_011513688.1

    UniProtKB/Swiss-Prot
    Q7Z602
    Conserved Domains (2) summary
    cd14964
    Location:1844
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:17295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  11. XM_017012165.1XP_016867654.1  probable G-protein coupled receptor 141 isoform X7

    UniProtKB/Swiss-Prot
    Q7Z602
    Conserved Domains (2) summary
    cd14964
    Location:1844
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:17295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  12. XM_011515385.2XP_011513687.1  probable G-protein coupled receptor 141 isoform X7

    See identical proteins and their annotated locations for XP_011513687.1

    UniProtKB/Swiss-Prot
    Q7Z602
    Conserved Domains (2) summary
    cd14964
    Location:1844
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:17295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
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