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ZACN zinc activated ion channel [ Homo sapiens (human) ]

Gene ID: 353174, updated on 2-Mar-2021

Summary

Official Symbol
ZACNprovided by HGNC
Official Full Name
zinc activated ion channelprovided by HGNC
Primary source
HGNC:HGNC:29504
See related
Ensembl:ENSG00000186919 MIM:610935
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L2; ZAC; ZAC1; LGICZ; LGICZ1
Summary
LGICZ1 is a zinc-activated ligand-gated ion channel that defines a new subgroup of the cysteine-loop superfamily of ligand-gated ion channels (Davies et al., 2003 [PubMed 12381728]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in prostate (RPKM 23.1), brain (RPKM 20.2) and 25 other tissues See more
Orthologs
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Genomic context

See ZACN in Genome Data Viewer
Location:
17q25.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (76079182..76082806)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74075263..74078887)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene envoplakin Neighboring gene signal recognition particle 68 Neighboring gene galanin receptor 2 Neighboring gene exocyst complex component 7 Neighboring gene microRNA 6868 Neighboring gene uncharacterized LOC101928447

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129841

Gene Ontology Provided by GOA

Function Evidence Code Pubs
extracellular ligand-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
ligand-gated ion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
nervous system process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to zinc ion IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc-activated ligand-gated ion channel
Names
ligand-gated ion channel subunit
ligand-gated ion channel zinc-activated 1
ligand-gated ion-channel receptor L2
zinc activated ligand-gated ion channel 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_180990.4NP_851321.2  zinc-activated ligand-gated ion channel precursor

    See identical proteins and their annotated locations for NP_851321.2

    Status: VALIDATED

    Source sequence(s)
    AB223030, AC018665, DB119720
    Consensus CDS
    CCDS11740.2
    UniProtKB/Swiss-Prot
    Q401N2
    Related
    ENSP00000334854.5, ENST00000334586.10
    Conserved Domains (2) summary
    TIGR00860
    Location:11368
    LIC; Cation transporter family protein
    pfam02931
    Location:54187
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    76079182..76082806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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