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C6orf58 chromosome 6 open reading frame 58 [ Homo sapiens (human) ]

Gene ID: 352999, updated on 5-Aug-2022

Summary

Official Symbol
C6orf58provided by HGNC
Official Full Name
chromosome 6 open reading frame 58provided by HGNC
Primary source
HGNC:HGNC:20960
See related
Ensembl:ENSG00000184530 AllianceGenome:HGNC:20960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LEG1
Summary
Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum (RPKM 281.8), stomach (RPKM 185.1) and 1 other tissue See more
Orthologs
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Genomic context

See C6orf58 in Genome Data Viewer
Location:
6q22.33
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (127577174..127591820)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (128766100..128780746)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (127898319..127912965)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene SOGA3-KIAA0408 readthrough Neighboring gene Sharpr-MPRA regulatory region 7566 Neighboring gene SOGA family member 3 Neighboring gene uncharacterized LOC107986642 Neighboring gene uncharacterized LOC105377995 Neighboring gene uncharacterized LOC105377996 Neighboring gene chromosome 6 open reading frame 58 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC72003

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein LEG1 homolog
Names
UPF0762 protein C6orf58
liver enriched gene 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010905.3NP_001010905.1  protein LEG1 homolog precursor

    See identical proteins and their annotated locations for NP_001010905.1

    Status: VALIDATED

    Source sequence(s)
    AK303850, AL583806
    Consensus CDS
    CCDS34533.1
    UniProtKB/Swiss-Prot
    Q5VUP2, Q6P5S2
    Related
    ENSP00000328069.7, ENST00000329722.8
    Conserved Domains (1) summary
    pfam05612
    Location:30305
    DUF781; Mouse protein of unknown function (DUF781)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    127577174..127591820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    128766100..128780746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)