Format

Send to:

Choose Destination

JCHAIN joining chain of multimeric IgA and IgM [ Homo sapiens (human) ]

Gene ID: 3512, updated on 1-Jun-2020

Summary

Official Symbol
JCHAINprovided by HGNC
Official Full Name
joining chain of multimeric IgA and IgMprovided by HGNC
Primary source
HGNC:HGNC:5713
See related
Ensembl:ENSG00000132465 MIM:147790
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IGJ; JCH; IGCJ
Expression
Biased expression in colon (RPKM 2264.9), duodenum (RPKM 2014.1) and 10 other tissues See more
Orthologs

Genomic context

See JCHAIN in Genome Data Viewer
Location:
4q13.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (70655541..70666508, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (71521258..71532348, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ameloblastin Neighboring gene enamelin Neighboring gene uncharacterized LOC101927297 Neighboring gene UTP3 small subunit processome component

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
IgA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
antigen binding NAS
Non-traceable Author Statement
more info
PubMed 
contributes_to immunoglobulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to immunoglobulin receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to immunoglobulin receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to peptidoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to phosphatidylcholine binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding, bridging IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
adaptive immune response IDA
Inferred from Direct Assay
more info
PubMed 
antibacterial humoral response IDA
Inferred from Direct Assay
more info
PubMed 
glomerular filtration IMP
Inferred from Mutant Phenotype
more info
PubMed 
humoral immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response NAS
Non-traceable Author Statement
more info
PubMed 
innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
positive regulation of respiratory burst IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
receptor-mediated endocytosis TAS
Traceable Author Statement
more info
 
retina homeostasis HEP PubMed 

General protein information

Preferred Names
immunoglobulin J chain
Names
IgJ chain
J chain
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144646.4NP_653247.1  immunoglobulin J chain precursor

    See identical proteins and their annotated locations for NP_653247.1

    Status: VALIDATED

    Source sequence(s)
    BC038982, BP221304, BP418109
    Consensus CDS
    CCDS3545.1
    UniProtKB/Swiss-Prot
    P01591
    Related
    ENSP00000254801.4, ENST00000254801.9
    Conserved Domains (1) summary
    pfam15097
    Location:24159
    Ig_J_chain; Immunoglobulin J chain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    70655541..70666508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center