Arr1 Arrestin 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Arr1provided by FlyBase
Official Full Name: Arrestin 1provided by FlyBase
Primary source: FLYBASE:FBgn0000120
Locus tag: Dmel_CG5711
See related: AllianceGenome:FB:FBgn0000120
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 3H10; Arr; arr1; ARR1; ArrA; CG5711; DA; DAI; DmArr1; Dmarrestin; DmArrestin-1; Dmel\CG5711; Dro.-Arr.I; DS-Ag; PRII
Summary: Predicted to enable G protein-coupled receptor binding activity and opsin binding activity. Involved in several processes, including photoreceptor cell maintenance; regulation of G protein-coupled receptor signaling pathway; and sensory perception of smell. Located in cytoplasm and rhabdomere. Is expressed in several structures, including adult head; testis; and visual system. Orthologous to human ARRB2 (arrestin beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (18078269..18081307)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (18078269..18081307)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables opsin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in desensitization of G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of opsin-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of opsin-mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of phospholipase C-activating phototransduction signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of phospholipase C-activating phototransduction signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in photoreceptor cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in rhabdomere	IDA Inferred from Direct Assay more info	PubMed

Names: Arr1-PA; Arr1-PB; Arr1-PC; Arrestin1; CG5711-PA; CG5711-PB; CG5711-PC; Phosrestin-II; arrestin; arrestin A; drosophila arrestin

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The following sections contain reference sequences that belong to a specific genome build. Explain