U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

IGHG4 immunoglobulin heavy constant gamma 4 (G4m marker) [ Homo sapiens (human) ]

Gene ID: 3503, updated on 22-Sep-2022

Summary

Official Symbol
IGHG4provided by HGNC
Official Full Name
immunoglobulin heavy constant gamma 4 (G4m marker)provided by HGNC
Primary source
HGNC:HGNC:5528
See related
Ensembl:ENSG00000211892 IMGT/GENE-DB:IGHG4; MIM:147130; AllianceGenome:HGNC:5528
Gene type
other
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in several processes, including activation of immune response; defense response to other organism; and phagocytosis. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See IGHG4 in Genome Data Viewer
Location:
14q32.33
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (105624476..105626065, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (99896471..99898060, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (106090813..106092402, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene microRNA 8071-1 Neighboring gene microRNA 8071-2 Neighboring gene immunoglobulin heavy constant epsilon Neighboring gene immunoglobulin heavy locus Neighboring gene immunoglobulin heavy constant gamma 2 (G2m marker)

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Other Names

  • immunoglobulin heavy chain constant region gamma 4

Clone Names

  • MGC117419

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables immunoglobulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in B cell receptor signaling pathway IC
Inferred by Curator
more info
PubMed 
involved_in adaptive immune response IC
Inferred by Curator
more info
PubMed 
involved_in complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phagocytosis, engulfment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phagocytosis, recognition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of B cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_001019.6 

    Range
    1254280..1255975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    105624476..105626065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187600.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    92245..93834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    99896471..99898060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)