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IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker) [ Homo sapiens (human) ]

Gene ID: 3501, updated on 5-Jul-2025
Official Symbol
IGHG2provided by HGNC
Official Full Name
immunoglobulin heavy constant gamma 2 (G2m marker)provided by HGNC
Primary source
HGNC:HGNC:5526
See related
Ensembl:ENSG00000211893 IMGT/GENE-DB:IGHG2; MIM:147110; AllianceGenome:HGNC:5526
Gene type
other
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in antibacterial humoral response and complement activation, classical pathway. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
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See IGHG2 in Genome Data Viewer
Location:
14q32.33
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (105643203..105644789, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (99915504..99917090, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (106109540..106111126, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene microRNA 8071-2 Neighboring gene immunoglobulin heavy locus Neighboring gene immunoglobulin heavy constant gamma 4 (G4m marker) Neighboring gene ETS transcription factor ELK2A, pseudogene Neighboring gene immunoglobulin heavy constant gamma P (non-functional) Neighboring gene immunoglobulin heavy constant alpha 1

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Other Names

  • Constant region of heavy chain of IgG2
  • immunoglobulin gamma 2 (Gm marker)
  • immunoglobulin heavy constant gamma 2 (Gm marker)

Clone Names

  • DKFZp686I04196

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables immunoglobulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in adaptive immune response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of IgG immunoglobulin complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in blood microparticle HDA PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space NAS
Non-traceable Author Statement
more info
PubMed 
part_of immunoglobulin complex IEA
Inferred from Electronic Annotation
more info
 
part_of immunoglobulin complex, circulating IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_001019.6 

    Range
    1235556..1237248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    105643203..105644789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187600.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    110972..112558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    99915504..99917090 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)