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IGFBP3 insulin like growth factor binding protein 3 [ Homo sapiens (human) ]

Gene ID: 3486, updated on 28-Nov-2021

Summary

Official Symbol
IGFBP3provided by HGNC
Official Full Name
insulin like growth factor binding protein 3provided by HGNC
Primary source
HGNC:HGNC:5472
See related
Ensembl:ENSG00000146674 MIM:146732
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IBP3; BP-53
Summary
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Biased expression in placenta (RPKM 686.3), endometrium (RPKM 259.6) and 7 other tissues See more
Orthologs
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Genomic context

See IGFBP3 in Genome Data Viewer
Location:
7p12.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (45912245..45921272, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (45951844..45960871, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 201 Neighboring gene insulin like growth factor binding protein 1 Neighboring gene uncharacterized LOC102723446 Neighboring gene RNA, U7 small nuclear 76 pseudogene Neighboring gene uncharacterized LOC105375264 Neighboring gene ferritin light chain pseudogene 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3.
GeneReviews: Not available
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
GeneReviews: Not available
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.
GeneReviews: Not available
Genome-wide association analyses identify variants in developmental genes associated with hypospadias.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables fibronectin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables insulin-like growth factor I binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables insulin-like growth factor I binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables insulin-like growth factor II binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables insulin-like growth factor binding NAS
Non-traceable Author Statement
more info
PubMed 
enables metal ion binding NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine phosphatase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
part_of insulin-like growth factor binding protein complex IC
Inferred by Curator
more info
PubMed 
part_of insulin-like growth factor ternary complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
insulin-like growth factor-binding protein 3
Names
IBP-3
IGF-binding protein 3
IGFBP-3
acid stable subunit of the 140 K IGF complex
binding protein 29
binding protein 53
growth hormone-dependent binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011508.1 RefSeqGene

    Range
    5001..14028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_68

mRNA and Protein(s)

  1. NM_000598.5NP_000589.2  insulin-like growth factor-binding protein 3 isoform b precursor

    See identical proteins and their annotated locations for NP_000589.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform b).
    Source sequence(s)
    AI142967, AK056274, AU102436, BC064987
    Consensus CDS
    CCDS5505.1
    UniProtKB/Swiss-Prot
    P17936
    UniProtKB/TrEMBL
    B3KPF0
    Related
    ENSP00000477772.2, ENST00000613132.5
    Conserved Domains (2) summary
    smart00121
    Location:38115
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:213285
    Thyroglobulin_1; Thyroglobulin type-1 repeat
  2. NM_001013398.2NP_001013416.1  insulin-like growth factor-binding protein 3 isoform a precursor

    See identical proteins and their annotated locations for NP_001013416.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC091524, AI142967, AL540642, BC064987, X64875
    Consensus CDS
    CCDS34632.1
    UniProtKB/Swiss-Prot
    P17936
    Related
    ENSP00000370473.4, ENST00000381083.9
    Conserved Domains (2) summary
    smart00121
    Location:38115
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:219291
    Thyroglobulin_1; Thyroglobulin type-1 repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    45912245..45921272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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