Format

Send to:

Choose Destination

ACSM2B acyl-CoA synthetase medium chain family member 2B [ Homo sapiens (human) ]

Gene ID: 348158, updated on 8-Jul-2021

Summary

Official Symbol
ACSM2Bprovided by HGNC
Official Full Name
acyl-CoA synthetase medium chain family member 2Bprovided by HGNC
Primary source
HGNC:HGNC:30931
See related
Ensembl:ENSG00000066813 MIM:614359
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HXMA; ACSM2; HYST1046
Expression
Restricted expression toward kidney (RPKM 155.6) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ACSM2B in Genome Data Viewer
Location:
16p12.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (20536226..20576376, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (20547548..20587689, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371119 Neighboring gene acyl-CoA synthetase medium chain family member 2A Neighboring gene uncharacterized LOC105371120 Neighboring gene acyl-coenzyme A synthetase ACSM5, mitochondrial-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Genetic determinants influencing human serum metabolome among African Americans.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables CoA-ligase activity TAS
Traceable Author Statement
more info
 
enables benzoate-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables butyrate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables decanoate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables fatty acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fatty-acyl-CoA synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
acyl-coenzyme A synthetase ACSM2B, mitochondrial
Names
acyl-CoA synthetase medium-chain family member 2
benzoate--CoA ligase
butyrate--CoA ligase 2B
butyryl-coenzyme A synthetase 2B
middle-chain acyl-CoA synthetase 2B
xenobiotic/medium-chain fatty acid-CoA ligase HXM-A
xenobiotic/medium-chain fatty acid:CoA ligase
NP_001098539.1
NP_872423.3
XP_005255361.1
XP_011544126.1
XP_016878694.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105069.2NP_001098539.1  acyl-coenzyme A synthetase ACSM2B, mitochondrial

    See identical proteins and their annotated locations for NP_001098539.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC141053, AC141273
    Consensus CDS
    CCDS10586.1
    UniProtKB/Swiss-Prot
    Q68CK6
    Related
    ENSP00000327453.6, ENST00000329697.10
    Conserved Domains (1) summary
    cl17068
    Location:40568
    AFD_class_I; Adenylate forming domain, Class I superfamily
  2. NM_182617.4NP_872423.3  acyl-coenzyme A synthetase ACSM2B, mitochondrial

    See identical proteins and their annotated locations for NP_872423.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AC141053, AC141273
    Consensus CDS
    CCDS10586.1
    UniProtKB/Swiss-Prot
    Q68CK6
    Related
    ENSP00000456378.1, ENST00000567001.5
    Conserved Domains (1) summary
    cl17068
    Location:40568
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    20536226..20576376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545824.3XP_011544126.1  acyl-coenzyme A synthetase ACSM2B, mitochondrial isoform X1

    UniProtKB/TrEMBL
    H3BTX9
    Related
    ENSP00000457377.1, ENST00000565322.5
    Conserved Domains (2) summary
    COG0365
    Location:2486
    Acs; Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]
    cl17068
    Location:1489
    AFD_class_I; Adenylate forming domain, Class I superfamily
  2. XM_005255304.4XP_005255361.1  acyl-coenzyme A synthetase ACSM2B, mitochondrial isoform X2

    Conserved Domains (2) summary
    COG0365
    Location:40413
    Acs; Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]
    cl17068
    Location:40427
    AFD_class_I; Adenylate forming domain, Class I superfamily
  3. XM_017023205.2XP_016878694.1  acyl-coenzyme A synthetase ACSM2B, mitochondrial isoform X3

RNA

  1. XR_001751899.2 RNA Sequence

Support Center