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ARPIN actin related protein 2/3 complex inhibitor [ Homo sapiens (human) ]

Gene ID: 348110, updated on 12-Oct-2019

Summary

Official Symbol
ARPINprovided by HGNC
Official Full Name
actin related protein 2/3 complex inhibitorprovided by HGNC
Primary source
HGNC:HGNC:28782
See related
Ensembl:ENSG00000242498 MIM:615543
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C15orf38
Expression
Ubiquitous expression in colon (RPKM 5.0), ovary (RPKM 4.4) and 24 other tissues See more
Orthologs

Genomic context

See ARPIN in Genome Data Viewer
Location:
15q26.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (89895006..89912952, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90443832..90456222, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ARPIN-AP3S2 readthrough Neighboring gene adaptor related protein complex 3 subunit sigma 2 Neighboring gene RNA, U6 small nuclear 1111, pseudogene Neighboring gene microRNA 5009 Neighboring gene RNA, U7 small nuclear 111 pseudogene Neighboring gene zinc finger and SCAN domain containing 5A pseudogene Neighboring gene zinc finger protein 710 Neighboring gene microRNA 3174

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Web-based, participant-driven studies yield novel genetic associations for common traits.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough ARPIN-AP3S2

Readthrough gene: ARPIN-AP3S2, Included gene: AP3S2

Homology

Clone Names

  • FLJ30690, MGC61550

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
directional locomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of lamellipodium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
arpin
Names
UPF0552 protein C15orf38
arp2/3 inhibition protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282380.1NP_001269309.1  arpin isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC027176, AK055252, AK093274, BC053602, BM023230
    Consensus CDS
    CCDS73780.1
    UniProtKB/Swiss-Prot
    Q7Z6K5
    UniProtKB/TrEMBL
    H0YMP5
    Related
    ENSP00000453687.1, ENST00000460685.1
    Conserved Domains (1) summary
    pfam10574
    Location:1128
    UPF0552; uncharacterized protein family UPF0552
  2. NM_182616.4NP_872422.1  arpin isoform 1

    See identical proteins and their annotated locations for NP_872422.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC027176, AK055252, BC053602, BM023230, DB285255
    Consensus CDS
    CCDS42080.1
    UniProtKB/Swiss-Prot
    Q7Z6K5
    Related
    ENSP00000350075.5, ENST00000357484.10
    Conserved Domains (1) summary
    pfam10574
    Location:1224
    UPF0552; uncharacterized protein family UPF0552

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    89895006..89912952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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