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APOD apolipoprotein D [ Homo sapiens (human) ]

Gene ID: 347, updated on 12-Sep-2021

Summary

Official Symbol
APODprovided by HGNC
Official Full Name
apolipoprotein Dprovided by HGNC
Primary source
HGNC:HGNC:612
See related
Ensembl:ENSG00000189058 MIM:107740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a component of high density lipoprotein that has no marked similarity to other apolipoprotein sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein superfamily of carrier proteins, also known as lipocalins. This glycoprotein is closely associated with the enzyme lecithin:cholesterol acyltransferase - an enzyme involved in lipoprotein metabolism. [provided by RefSeq, Aug 2008]
Expression
Broad expression in fat (RPKM 368.7), brain (RPKM 153.2) and 16 other tissues See more
Orthologs
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Genomic context

See APOD in Genome Data Viewer
Location:
3q29
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (195568705..195583940, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (195295576..195310811, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 73, pseudogene Neighboring gene RPL24 pseudogene 6 Neighboring gene mucin 20, cell surface associated pseudogene 1 Neighboring gene uncharacterized LOC107986029

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cholesterol binding IDA
Inferred from Direct Assay
more info
PubMed 
enables lipid transporter activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in aging NAS
Non-traceable Author Statement
more info
PubMed 
involved_in angiogenesis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in brain development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glucose metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of T cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cytokine production involved in inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of lipoprotein lipid oxidation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of monocyte chemotactic protein-1 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of platelet-derived growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of smooth muscle cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peripheral nervous system axon regeneration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to axon injury ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to reactive oxygen species IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to reactive oxygen species IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to xenobiotic stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in tissue regeneration ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosolic ribosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular region HDA PubMed 
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
apolipoprotein D
Names
apo-D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001647.4NP_001638.1  apolipoprotein D precursor

    See identical proteins and their annotated locations for NP_001638.1

    Status: REVIEWED

    Source sequence(s)
    BC007402, BU727194, DA892855
    Consensus CDS
    CCDS33925.1
    UniProtKB/Swiss-Prot
    P05090
    Related
    ENSP00000345179.3, ENST00000343267.8
    Conserved Domains (1) summary
    cd19437
    Location:25182
    lipocalin_apoD-like; apolipoprotein D and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    195568705..195583940 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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