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OR2A1 olfactory receptor family 2 subfamily A member 1 [ Homo sapiens (human) ]

Gene ID: 346528, updated on 10-Oct-2024

Summary

Official Symbol
OR2A1provided by HGNC
Official Full Name
olfactory receptor family 2 subfamily A member 1provided by HGNC
Primary source
HGNC:HGNC:8229
See related
Ensembl:ENSG00000221970 AllianceGenome:HGNC:8229
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See OR2A1 in Genome Data Viewer
Location:
7q35
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (144312079..144322737)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (145494326..145504649)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (144009512..144019830)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ARHGEF35 antisense RNA 1 Neighboring gene OR2A1 antisense RNA 1 Neighboring gene Rho guanine nucleotide exchange factor 34, pseudogene Neighboring gene CTAGE family member 8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:143981368-143982251 Neighboring gene olfactory receptor family 2 subfamily A member 9 pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:144039739-144040663 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:144050275-144050774 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:144062707-144063275 Neighboring gene Rho guanine nucleotide exchange factor 5 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:144075440-144076639 Neighboring gene MPRA-validated peak6811 silencer Neighboring gene uncharacterized LOC124901817

Genomic regions, transcripts, and products

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
olfactory receptor 2A1/2A42
Names
olfactory receptor OR7-16
olfactory receptor OR7-19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005287.2NP_001005287.1  olfactory receptor 2A1/2A42

    See identical proteins and their annotated locations for NP_001005287.1

    Status: VALIDATED

    Source sequence(s)
    AC074386
    Consensus CDS
    CCDS43673.1
    UniProtKB/Swiss-Prot
    Q6IF44, Q8NGT9, Q96R46
    UniProtKB/TrEMBL
    A0A2R8YEV3
    Related
    ENSP00000493454.1, ENST00000641044.2
    Conserved Domains (2) summary
    pfam00001
    Location:40289
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:30304
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    144312079..144322737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420323.1XP_047276279.1  olfactory receptor 2A1/2A42 isoform X1

    UniProtKB/Swiss-Prot
    Q6IF44, Q8NGT9, Q96R46

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654715.1 Reference GRCh38.p14 PATCHES

    Range
    266818..277372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332179.1XP_054188154.1  olfactory receptor 2A1/2A42 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    145494326..145504649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)