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OSTN osteocrin [ Homo sapiens (human) ]

Gene ID: 344901, updated on 5-Aug-2022

Summary

Official Symbol
OSTNprovided by HGNC
Official Full Name
osteocrinprovided by HGNC
Primary source
HGNC:HGNC:29961
See related
Ensembl:ENSG00000188729 MIM:610280; AllianceGenome:HGNC:29961
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MUSCLIN
Summary
Predicted to enable signaling receptor binding activity. Involved in negative regulation of dendrite extension. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See OSTN in Genome Data Viewer
Location:
3q28
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (191199241..191265615)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (194014945..194081320)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (190917030..190983404)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene small NF90 (ILF3) associated RNA I Neighboring gene uncharacterized LOC107986171 Neighboring gene OSTN antisense RNA 1 Neighboring gene urotensin 2B Neighboring gene coiled-coil domain containing 50 Neighboring gene Sharpr-MPRA regulatory region 6572

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in endochondral bone growth IEA
Inferred from Electronic Annotation
more info
 
involved_in hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of dendrite extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glucose import IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198184.2NP_937827.1  osteocrin precursor

    See identical proteins and their annotated locations for NP_937827.1

    Status: VALIDATED

    Source sequence(s)
    AC126567, AY398681
    Consensus CDS
    CCDS3299.1
    UniProtKB/Swiss-Prot
    A1A4U3, P61366
    Related
    ENSP00000508312.1, ENST00000682035.1
    Conserved Domains (1) summary
    pfam11037
    Location:1133
    Musclin; Insulin-resistance promoting peptide in skeletal muscle

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    191199241..191265615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006303.3XP_016861792.1  osteocrin isoform X1

    UniProtKB/Swiss-Prot
    A1A4U3, P61366
    Conserved Domains (1) summary
    pfam11037
    Location:1133
    Musclin; Insulin-resistance promoting peptide in skeletal muscle

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    194014945..194081320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)