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OSTN osteocrin [ Homo sapiens (human) ]

Gene ID: 344901, updated on 23-Nov-2023

Summary

Official Symbol
OSTNprovided by HGNC
Official Full Name
osteocrinprovided by HGNC
Primary source
HGNC:HGNC:29961
See related
Ensembl:ENSG00000188729 MIM:610280; AllianceGenome:HGNC:29961
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MUSCLIN
Summary
Predicted to enable signaling receptor binding activity. Involved in negative regulation of dendrite extension. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See OSTN in Genome Data Viewer
Location:
3q28
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (191199241..191265615)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (194014945..194081320)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (190917030..190983404)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene small NF90 (ILF3) associated RNA I Neighboring gene ReSE screen-validated silencer GRCh37_chr3:190686471-190686660 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20987 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_66920 Neighboring gene uncharacterized LOC107986171 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:190875631-190876830 Neighboring gene NANOG hESC enhancer GRCh37_chr3:190909180-190909700 Neighboring gene OSTN antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20989 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20990 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:191019724-191020249 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:191046750-191047351 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:191047352-191047952 Neighboring gene urotensin 2B Neighboring gene Sharpr-MPRA regulatory region 6572 Neighboring gene coiled-coil domain containing 50 Neighboring gene PYDC2 antisense RNA 1 Neighboring gene pyrin domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in endochondral bone growth IEA
Inferred from Electronic Annotation
more info
 
involved_in hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of dendrite extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glucose import IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198184.2NP_937827.1  osteocrin precursor

    See identical proteins and their annotated locations for NP_937827.1

    Status: VALIDATED

    Source sequence(s)
    AC126567, AY398681
    Consensus CDS
    CCDS3299.1
    UniProtKB/Swiss-Prot
    A1A4U3, P61366
    Related
    ENSP00000508312.1, ENST00000682035.1
    Conserved Domains (1) summary
    pfam11037
    Location:1133
    Musclin; Insulin-resistance promoting peptide in skeletal muscle

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    191199241..191265615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006303.3XP_016861792.1  osteocrin isoform X1

    UniProtKB/Swiss-Prot
    A1A4U3, P61366
    Conserved Domains (1) summary
    pfam11037
    Location:1133
    Musclin; Insulin-resistance promoting peptide in skeletal muscle

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    194014945..194081320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346433.1XP_054202408.1  osteocrin isoform X1

    UniProtKB/Swiss-Prot
    A1A4U3, P61366