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RFPL4A ret finger protein like 4A [ Homo sapiens (human) ]

Gene ID: 342931, updated on 2-Nov-2024

Summary

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Official Symbol
RFPL4Aprovided by HGNC
Official Full Name
ret finger protein like 4Aprovided by HGNC
Primary source
HGNC:HGNC:16449
See related
Ensembl:ENSG00000223638 MIM:612601; AllianceGenome:HGNC:16449
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RFPL4; RNF210
Summary
Predicted to enable protein homodimerization activity; protein kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of autophagy; positive regulation of canonical NF-kappaB signal transduction; and regulation of viral entry into host cell. Predicted to be located in female germ cell nucleus. Predicted to be active in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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See RFPL4A in Genome Data Viewer
Location:
19q13.42
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55757294..55763421)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58856647..58862774)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56270463..56274787)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NLR family pyrin domain containing 9 Neighboring gene RN7SK pseudogene 109 Neighboring gene uncharacterized LOC105372465 Neighboring gene ret finger protein like 4A like 1 Neighboring gene ret finger protein like 4A pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RFPL4A increases the G1 population and decreases sensitivity to chemotherapy in human colorectal cancer cells. Naito A, et al. J Biol Chem, 2015 Mar 6. PMID 25605732, Free PMC Article
  2. Structure of the PRYSPRY-domain: implications for autoinflammatory diseases. Grütter C, et al. FEBS Lett, 2006 Jan 9. PMID 16364311
  3. The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells. Rajkovic A, et al. Mech Dev, 2002 Mar. PMID 11850190
  4. Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. GENDEP Investigators, et al. Am J Psychiatry, 2013 Feb. PMID 23377640, Free PMC Article
  5. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results indicate that RFPL4A is a novel factor that increases the G1 population and decreases sensitivity to chemotherapy and thus may be a promising therapeutic target for refractory tumor conditions.
    Title: RFPL4A increases the G1 population and decreases sensitivity to chemotherapy in human colorectal cancer cells.
  2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  3. The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells.
    Title: The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ret finger protein-like 4A
Names
RING finger protein 210
ret finger protein-like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145014.2 → NP_001138486.1  ret finger protein-like 4A

    See identical proteins and their annotated locations for NP_001138486.1

    Status: VALIDATED

    Source sequence(s)
    AC008749
    Consensus CDS
    CCDS46201.1
    UniProtKB/Swiss-Prot
    A6NLU0
    Related
    ENSP00000392936.2, ENST00000434937.3
    Conserved Domains (3) summary
    pfam11002
    Location:54 → 95
    RDM; RFPL defining motif (RDM)
    pfam15227
    Location:11 → 52
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd15821
    Location:93 → 270
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    55757294..55763421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526915.4 → XP_011525217.1  ret finger protein-like 4A isoform X1

    Conserved Domains (3) summary
    pfam11002
    Location:111 → 152
    RDM; RFPL defining motif (RDM)
    pfam15227
    Location:68 → 109
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd15821
    Location:150 → 327
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    58856647..58862774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320848.1 → XP_054176823.1  ret finger protein-like 4A isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NLU0.3 GenPept UniProtKB/Swiss-Prot:A6NLU0

Gene LinkOut

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