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GOLGA6A golgin A6 family member A [ Homo sapiens (human) ]

Gene ID: 342096, updated on 17-Jun-2019

Summary

Official Symbol
GOLGA6Aprovided by HGNC
Official Full Name
golgin A6 family member Aprovided by HGNC
Primary source
HGNC:HGNC:13567
See related
Ensembl:ENSG00000159289 MIM:610288
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLP; GOLGA6
Summary
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The protein encoded by this gene is a member of the golgin family of proteins, whose members localize to the Golgi. This gene is found in a large, low copy repeat sequence or duplicon that is found in multiple copies, that are greather than 90% similar, on chromosome 15. Duplicons are associated with deletions, inversions and other chromosome rearrangements that underlie genomic disease. The protein encoded by this gene is thought to be a functional golgin protein while the majority of the related copies of this gene are thought to be transcribed pseudogenes. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 17.2) See more
Orthologs

Genomic context

See GOLGA6A in Genome Data Viewer
Location:
15q24.1
Exon count:
18
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (74069857..74082550, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (74362198..74374891, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene promyelocytic leukemia Neighboring gene dynamin 1 pseudogene 33 Neighboring gene RNA, 7SL, cytoplasmic 429, pseudogene Neighboring gene uncharacterized LOC107987224 Neighboring gene COMM domain containing 4 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ75859

Gene Ontology Provided by GOA

Process Evidence Code Pubs
Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi cis cisterna IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi cisterna membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
golgin subfamily A member 6A
Names
Golgin linked to PML
golgi autoantigen, golgin subfamily a, 6
golgi autoantigen, golgin subfamily a, 6A
golgi autoantigen, golgin subfamily a, member 6
golgin-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038640.2NP_001033729.2  golgin subfamily A member 6A

    See identical proteins and their annotated locations for NP_001033729.2

    Status: VALIDATED

    Source sequence(s)
    AC013486, AF263742, BC131515
    Consensus CDS
    CCDS32290.1
    UniProtKB/Swiss-Prot
    Q9NYA3
    UniProtKB/TrEMBL
    A2VDJ1
    Related
    ENSP00000290438.3, ENST00000290438.3
    Conserved Domains (2) summary
    pfam01496
    Location:264346
    V_ATPase_I; V-type ATPase 116kDa subunit family
    pfam15070
    Location:217686
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    74069857..74082550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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