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SLC35F4 solute carrier family 35 member F4 [ Homo sapiens (human) ]

Gene ID: 341880, updated on 2-Nov-2024

Summary

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Official Symbol
SLC35F4provided by HGNC
Official Full Name
solute carrier family 35 member F4provided by HGNC
Primary source
HGNC:HGNC:19845
See related
Ensembl:ENSG00000151812 AllianceGenome:HGNC:19845
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf36; c14_5373
Summary
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
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Genomic context

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See SLC35F4 in Genome Data Viewer
Location:
14q22.3-q23.1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (57563920..57983181, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (51770870..52190085, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (58030638..58332810, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:57857288-57858283 Neighboring gene N-alpha-acetyltransferase 30, NatC catalytic subunit Neighboring gene uncharacterized LOC105370519 Neighboring gene coiled-coil domain containing 198 Neighboring gene uncharacterized LOC105370518 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:58047958-58049157 Neighboring gene serine and arginine rich splicing factor 10 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:58181078-58182074 Neighboring gene NANOG hESC enhancer GRCh37_chr14:58220473-58221005 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:58252116-58253315 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:58266137-58266636 Neighboring gene NANOG hESC enhancer GRCh37_chr14:58282822-58283323 Neighboring gene RN7SK pseudogene 99 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_34475 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_34518 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:58418179-58418679 Neighboring gene Sharpr-MPRA regulatory region 5436 Neighboring gene armadillo like helical domain containing 4 Neighboring gene polycomb group ring finger 3 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr14:58587185-58587752 Neighboring gene NANOG hESC enhancer GRCh37_chr14:58595390-58595891 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. Jiang Y, et al. Genet Epidemiol, 2011 Feb. PMID 21254220, Free PMC Article
  2. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Wellcome Trust Case Control Consortium. Nature, 2007 Jun 7. PMID 17554300, Free PMC Article
  3. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. Wang KS, et al. Schizophr Res, 2010 Dec. PMID 20889312
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
EBI GWAS Catalog
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
EBI GWAS Catalog
Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Clone Names

  • FLJ37712

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 35 member F4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206920.2 → NP_001193849.1  solute carrier family 35 member F4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a. The exon combination of this variant is inferred from partial transcript and RNA-seq alignments.
    Source sequence(s)
    AL049838, AL136520, AL161804, BC101320, BX107164
    UniProtKB/Swiss-Prot
    A4IF30, A6NDQ3
    Conserved Domains (1) summary
    COG0697
    Location:237 → 437
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]

  2. NM_001306087.2 → NP_001293016.1  solute carrier family 35 member F4 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). The exon combination of this variant is inferred from partial transcript and RNA-seq alignments.
    Source sequence(s)
    AL049838, AL161804, BC101319, BC101321, BX107164, EG328127
    Consensus CDS
    CCDS76684.1
    UniProtKB/Swiss-Prot
    A4IF30, A6NDQ3
    UniProtKB/TrEMBL
    G3V4Z9
    Related
    ENSP00000452086.1, ENST00000556826.6
    Conserved Domains (1) summary
    COG0697
    Location:238 → 438
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]

  3. NM_001352011.2 → NP_001338940.1  solute carrier family 35 member F4 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL049838, AL136520, AL161804
    Conserved Domains (1) summary
    pfam06027
    Location:238 → 287
    SLC35F; Solute carrier family 35

  4. NM_001352012.2 → NP_001338941.1  solute carrier family 35 member F4 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL049838, AL132668, AL136520, AL161804
    UniProtKB/Swiss-Prot
    A4IF30, A6NDQ3
    Conserved Domains (1) summary
    COG0697
    Location:216 → 416
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]

  5. NM_001352013.2 → NP_001338942.1  solute carrier family 35 member F4 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL049838, AL136520, AL161804

  6. NM_001352014.2 → NP_001338943.1  solute carrier family 35 member F4 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL049838, AL136520, AL161804
    Consensus CDS
    CCDS86392.1
    Related
    ENSP00000451990.1, ENST00000554729.5

  7. NM_001352015.3 → NP_001338944.1  solute carrier family 35 member F4 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL049838, AL136520, AL161804
    UniProtKB/Swiss-Prot
    A4IF30, A6NDQ3
    Related
    ENSP00000342518.6, ENST00000339762.10
    Conserved Domains (1) summary
    COG0697
    Location:235 → 435
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]

  8. NM_001352016.2 → NP_001338945.1  solute carrier family 35 member F4 isoform h

    Status: VALIDATED

    Source sequence(s)
    AL049838, AL136520, AL161804

RNA

  1. NR_159373.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL049838, AL136520, AL161804

  2. NR_159374.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL049838, AL136520, AL161804

  3. NR_159375.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL049838, AL136520, AL161804

  4. NR_159376.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL049838, AL136520, AL161804

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    57563920..57983181 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536723.4 → XP_011535025.1  solute carrier family 35 member F4 isoform X3

    UniProtKB/Swiss-Prot
    A4IF30, A6NDQ3
    Conserved Domains (1) summary
    COG0697
    Location:225 → 425
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]

  2. XM_011536724.4 → XP_011535026.1  solute carrier family 35 member F4 isoform X4

    UniProtKB/Swiss-Prot
    A4IF30, A6NDQ3
    Conserved Domains (1) summary
    COG0697
    Location:220 → 420
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]

  3. XM_011536721.4 → XP_011535023.1  solute carrier family 35 member F4 isoform X2

    UniProtKB/Swiss-Prot
    A4IF30, A6NDQ3
    Conserved Domains (1) summary
    COG0697
    Location:284 → 484
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]

  4. XM_011536720.4 → XP_011535022.1  solute carrier family 35 member F4 isoform X1

    UniProtKB/Swiss-Prot
    A4IF30, A6NDQ3
    Conserved Domains (1) summary
    COG0697
    Location:285 → 485
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]

  5. XM_047431343.1 → XP_047287299.1  solute carrier family 35 member F4 isoform X5

  6. XM_024449561.2 → XP_024305329.1  solute carrier family 35 member F4 isoform X6

RNA

  1. XR_943418.4 RNA Sequence

  2. XR_002957548.2 RNA Sequence

  3. XR_007064010.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    51770870..52190085 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375982.1 → XP_054231957.1  solute carrier family 35 member F4 isoform X3

  2. XM_054375983.1 → XP_054231958.1  solute carrier family 35 member F4 isoform X4

  3. XM_054375981.1 → XP_054231956.1  solute carrier family 35 member F4 isoform X2

  4. XM_054375980.1 → XP_054231955.1  solute carrier family 35 member F4 isoform X1

  5. XM_054375984.1 → XP_054231959.1  solute carrier family 35 member F4 isoform X5

  6. XM_054375985.1 → XP_054231960.1  solute carrier family 35 member F4 isoform X6

RNA

  1. XR_008488863.1 RNA Sequence

  2. XR_008488864.1 RNA Sequence

  3. XR_008488862.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080455.1: Suppressed sequence

    Description
    NM_001080455.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4IF30.2 GenPept UniProtKB/Swiss-Prot:A4IF30

Gene LinkOut

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