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SLC35F4 solute carrier family 35 member F4 [ Homo sapiens (human) ]

Gene ID: 341880, updated on 22-Aug-2020

Summary

Official Symbol
SLC35F4provided by HGNC
Official Full Name
solute carrier family 35 member F4provided by HGNC
Primary source
HGNC:HGNC:19845
See related
Ensembl:ENSG00000151812
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf36; c14_5373
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See SLC35F4 in Genome Data Viewer
Location:
14q22.3-q23.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (57563920..57982327, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (58030640..58332592, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene N-alpha-acetyltransferase 30, NatC catalytic subunit Neighboring gene uncharacterized LOC112268129 Neighboring gene coiled-coil domain containing 198 Neighboring gene uncharacterized LOC105370519 Neighboring gene uncharacterized LOC105370518 Neighboring gene serine and arginine rich splicing factor 10 pseudogene Neighboring gene RN7SK pseudogene 99 Neighboring gene armadillo like helical domain containing 4 Neighboring gene polycomb group ring finger 3 pseudogene Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
GeneReviews: Not available
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
GeneReviews: Not available
Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
GeneReviews: Not available

General gene information

Markers

Homology

Clone Names

  • FLJ37712

Gene Ontology Provided by GOA

Function Evidence Code Pubs
transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
solute carrier family 35 member F4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206920.2NP_001193849.1  solute carrier family 35 member F4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a. The exon combination of this variant is inferred from partial transcript and RNA-seq alignments.
    Source sequence(s)
    AL049838, AL136520, AL161804, BC101320, BX107164
    UniProtKB/Swiss-Prot
    A4IF30
    Conserved Domains (1) summary
    COG0697
    Location:237437
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
  2. NM_001306087.2NP_001293016.1  solute carrier family 35 member F4 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). The exon combination of this variant is inferred from partial transcript and RNA-seq alignments.
    Source sequence(s)
    AL049838, AL161804, BC101319, BC101321, BX107164, EG328127
    Consensus CDS
    CCDS76684.1
    UniProtKB/Swiss-Prot
    A4IF30
    UniProtKB/TrEMBL
    G3V4Z9
    Related
    ENSP00000452086.1, ENST00000556826.6
    Conserved Domains (1) summary
    COG0697
    Location:238438
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
  3. NM_001352011.2NP_001338940.1  solute carrier family 35 member F4 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL049838, AL136520, AL161804
    Conserved Domains (1) summary
    pfam06027
    Location:238287
    SLC35F; Solute carrier family 35
  4. NM_001352012.2NP_001338941.1  solute carrier family 35 member F4 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL049838, AL132668, AL136520, AL161804
    Conserved Domains (1) summary
    COG0697
    Location:216416
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
  5. NM_001352013.2NP_001338942.1  solute carrier family 35 member F4 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL049838, AL136520, AL161804
  6. NM_001352014.2NP_001338943.1  solute carrier family 35 member F4 isoform f precursor

    Status: VALIDATED

    Source sequence(s)
    AL049838, AL136520, AL161804
    Consensus CDS
    CCDS86392.1
    Related
    ENSP00000451990.1, ENST00000554729.5
  7. NM_001352015.3NP_001338944.1  solute carrier family 35 member F4 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL049838, AL136520, AL161804
    Related
    ENSP00000342518.6, ENST00000339762.10
    Conserved Domains (1) summary
    COG0697
    Location:235435
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
  8. NM_001352016.2NP_001338945.1  solute carrier family 35 member F4 isoform h

    Status: VALIDATED

    Source sequence(s)
    AL049838, AL136520, AL161804

RNA

  1. NR_159373.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL049838, AL136520, AL161804
  2. NR_159374.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL049838, AL136520, AL161804
  3. NR_159375.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL049838, AL136520, AL161804
  4. NR_159376.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL049838, AL136520, AL161804

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    57563920..57982327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536723.3XP_011535025.1  solute carrier family 35 member F4 isoform X3

    Conserved Domains (1) summary
    COG0697
    Location:225425
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
  2. XM_011536724.3XP_011535026.1  solute carrier family 35 member F4 isoform X4

    Conserved Domains (1) summary
    COG0697
    Location:220420
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
  3. XM_011536720.3XP_011535022.1  solute carrier family 35 member F4 isoform X1

    Conserved Domains (1) summary
    COG0697
    Location:285485
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
  4. XM_017021260.2XP_016876749.1  solute carrier family 35 member F4 isoform X5

    UniProtKB/Swiss-Prot
    A4IF30
    Conserved Domains (1) summary
    pfam06027
    Location:115260
    SLC35F; Solute carrier family 35
  5. XM_011536721.3XP_011535023.1  solute carrier family 35 member F4 isoform X2

    Conserved Domains (1) summary
    COG0697
    Location:284484
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
  6. XM_024449561.1XP_024305329.1  solute carrier family 35 member F4 isoform X7

  7. XM_017021261.1XP_016876750.1  solute carrier family 35 member F4 isoform X6

RNA

  1. XR_943418.3 RNA Sequence

  2. XR_002957548.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080455.1: Suppressed sequence

    Description
    NM_001080455.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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